影响2型糖尿病老年患者并发周围神经病变的logistic分析

Logistic analysis of factors affecting peripheral nerve lesions in elderly patients with type 2 diabetes mellitus

目的探讨2型糖尿病老年患者并发周围神经病变的影响因素。方法选取2016年2月-2018年7月本院治疗的2型糖尿病老年患者120例作为研究对象,统计并发周围神经病变发生情况,根据有无发生周围神经病变分为DPN组57例和非DPN组63例,并对其影响因素进行调查分析。结果 DPN组患者与非DPN组患者的年龄、糖尿病病程、吸烟史、饮酒史、高血压病史、高血脂病史、BMI指数、FPG、HbA1c、UA水平差异有统计学意义(P<0.05),DPN组患者与非DPN组患者的性别、ALT、AST水平差异无统计学意义(P>0.05);Logisitic回归分析结果显示,年龄、糖尿病病程、吸烟史、饮酒史、高血压病史、高血脂病史、BMI指数、FPG、HbA1c、UA水平是2型糖尿病老年患者并发周围神经病变的影响因素。结论年龄、糖尿病病程、吸烟史、饮酒史、高血压病史、高血脂病史、BMI指数、FPG、HbA1c、UA水平是2型糖尿病老年患者并发周围神经病变的影响因素,应积极采取有效措施进行控制糖尿病周围神经病变的发生与发展,提高2型糖尿病老年患者的生活质量。

Objective To investigate the influencing factors of peripheral nerve lesionsin elderly patients with type2 diabetes mellitus(T2 DM). Methods A total of 120 elderly T2 DMpatients in a hospital from February 2016 to July 2018 were enrolled. The occurrence of peripheral nerve lesionswas statistically analyzed. According to the presence or absence of peripheral nerve lesions, they were divided into a DPN group(57 cases) and non-DPN group(63 cases). The influencing factors were investigated and analyzed. Results There were significant differencesbetween the DPN group and non-DPN group in age, the diabetes duration, smoking history, drinking history, hypertension history, hyperlipidemia history, BMI index, fasting blood glucose(FPG), glycosylated hemoglobin(HbA1 c) and uric acid(UA) levels(P<0.05).There was no significant differencebetween the DPN group and non-DPN group in the gender, alanine aminotransferase(ALT) level or aspartate aminotransferase(AST) level(P>0.05). Logisticregression analysis showed that age, the diabetes duration, smoking history, drinking history, history of hypertension, history of hyperlipidemia, BMI index, FPG, HbA1 c,and UA levels were the influencing factors of peripheral nerve lesionsin elderly T2 DM patients. Conclusion Age, the diabetes duration, smoking history, drinking history, history of hypertension, history of hyperlipidemia, BMI index, FPG, HbA1 c,and UA levels are independent risk factors of peripheral nerve lesionsin elderly T2 DM patients.Active measures should be taken actively to control the occurrence and development of diabetic peripheral nerve lesions, and improve the quality of life in elderly T2 DM patients.