舒洛地特对糖尿病患者眼底血流及氧化应激因子水平的影响

Effect of sulodexide on the level of stress factors in patients with diabetic fundus blood flow and oxidation

目的探讨舒洛地特在糖尿病患者中运用对患者眼底血流及氧化应激水平的影响。方法 2016年11月-2017年11月在本院治疗的糖尿病视网膜病变患者120例作为研究对象,按照数字表法分为观察组和对照组各60例,对照组糖尿病视网膜病变的常规治疗,观察组患者在对照组患者的基础上联合舒洛地特治疗,对比2组患者眼底血流及血清中氧化应激因子水平。结果治疗后2组患者MDA、AOPP均较前下降,且观察组低于对照组患者;治疗后2组患者抗氧化物GSH-PX、SOD较前明显上升,治疗后观察组患者PSV、EDV、PI均明显优于对照组患者,观察组患者治疗有效、好转人数均高于对照组患者。结论舒洛地特有助于降低机体氧化应激水平、改善眼底血流。

Objective To investigate the effect of sulodexide on the fundus blood flow and oxidative stress in diabetic patients.Methods 120 cases of diabetic retinopathy treated in our hospital from November 2016 to November 2017 were studied. The subjects were divided into the observation group and the control group,with 60 cases in each group. The control group was treated with the routine treatment of diabetic retinopathy. The patients in the observation group were combined with sulodexide on the basis of the treatment group. The fundus blood flow and serum levels of oxidative stress in two groups were compared.Results After treatment,MDA and AOPP decreased in the two groups,and the observation group was lower than the control group. After treatment,the antioxidant GSH-PX and SOD increased significantly in the two groups. After treatment,PSV,EDV and PI in the observation group were significantly higher than those in the control group. The number of effective and improved patients in the observation group was higher than that in the control group. Conclusion Sulodexide helps to reduce oxidative stress and improve the eye ground blood flow.