急性缺血性脑卒中患者血BUN/Cr比值的升高与静脉血栓栓塞症相关性研究

Correlation between elevated blood BUN/Cr ratio and venous thromboembolism in patients with acute ischemic stroke

目的研究急性缺血性脑卒中(acute ischemic stroke,AIS)患者血BUN/Cr比值的升高与静脉血栓栓塞症(venous thrombus embolism,VTE)之间的相关性。方法选取192例新诊断为AIS住院时间至少4周的患者分为非VTE组和VTE组,对临床基线特征及实验室数据进行分析。结果 192例患者中,20例(10. 5%)在住院期间发生VTE,BUN/Cr比值较高,在多变量分析中,BUN/Cr> 15(OR=8. 75)和严重的下肢无力(OR=4. 38)是VTE的独立危险因素(P <0. 05)。结论 AIS患者入院时BUN/Cr> 15作为脱水状态指标可能与VTE的发生相关。

Objective To study the correlation between the elevated blood urea nitrogen( BUN)/creatinine( Cr) ratio and venous thrombus embolism( VTE) in patients with acute ischemic stroke( AIS). Methods The 192 patients newly diagnosed with AIS for at least 4 weeks were divided into non-VTE group and VTE group,and the clinical baseline characteristics and laboratory data were analyzed. Results Of the 192 patients,20( 10. 5%) had VTE during hospitalization,BUN/Cr ratio was higher in a multivariate analysis. BUN/Cr > 15( OR = 8. 75) and severe lower limb weakness( OR = 4. 38) were independent risk factors for VTE. Conclusion BUN/Cr > 15,as an indicator of dehydration status,can predict the occurrence of VTE when AIS patients are admitted to hospital.