沈阳地区2015年-2017年诺如病毒感染性腹泻监测结果分析

Monitoring results analysis of norovirus infected diarrhea in Shenyang from 2015 to 2017

目的了解沈阳地区诺如病毒感染性腹泻流行病学特征。方法收集2015年-2017年沈阳地区4家哨点医院肠道监测门诊腹泻病例的粪便标本,采用实时荧光定量RT-PCR检测诺如病毒GⅠ和GⅡ基因型。结果共收集检测腹泻病例粪便标本1 505份,诺如病毒阳性161份,阳性率为10. 70%;基因型以GⅡ型为主(86. 96%),10岁以下儿童的发病率最高,为50例,占阳性率的31. 06%(50/161)。一年中,夏季检出率最低。结论诺如病毒对沈阳地区各年龄组人群均有不同程度的影响,尤其在儿童腹泻病例中较为常见,并呈现明显的季节性流行特征。沈阳地区诺如病毒的主要型别为GⅡ型。

Objective To investigate the epidemiology characteristics of norovirus among diarrheal outpatients in Shenyang.Methods Fecal specimens of diarrhea cases in the intestinal monitoring outpatients of four sentinel hospitals in Shenyang from2015 to 2017 were collected. Real-time quantitative RT-PCR was used to detect Norovirus G Ⅰ and G Ⅱ genomes.Results A total of 1 505 stool specimens were collected from diarrhea cases,161 were positive for Norovirus,the positive rate was 10. 70%;the genotype was mainly GⅡ( 86. 96%),and the incidence rate was highest in children under 10 years old,accounting for 50 cases. The rate was 31. 06%( 50/161). During the year,the summer detection rate was the lowest.Conclusion Norovirus has different degrees of influence on people of all age groups in Shenyang,especially in children with diarrhea,and it has obvious seasonal epidemic characteristics. The main type of Norovirus in Shenyang is GⅡ.