麦粒灸结合药物治疗对少弱精子症精子质量的影响

Effect on sperm quality of asthenospermia and oligospermia treated with grain-moxibustion combined with medicine therapy

目的:观察麦粒灸配合药物治疗少弱精子症的临床效果.方法:将60例患者按1︰1比例随机分为观察组(30例)和对照组(30例).对照组常规口服维生素E胶丸1次1粒,每日2次,五子衍宗丸1次1袋(6 g),每日3次,共治疗3个月;观察组在口服以上药物基础上加用麦粒灸治疗,穴取关元、肾俞、足三里,每周治疗1次,治疗3个月,共12次.采用全自动精子质量分析系统测定两组精子浓度和精子前向活率(PR),并比较两组临床疗效;采用精子核染色体结构检测(SCSA)方法检测观察组精子DNA碎片指数(DFI).结果:①两组治疗1、2、3个月后精子浓度和精子PR均较治疗前增加(P<0.01),且随治疗时间延长递增;两组内治疗2个月与1个月、治疗3个月与2个月比较,精子浓度和精子PR均明显增加(P<0.01);治疗1、2、3个月后,观察组精子浓度高于对照组(P<0.01);治疗3个月后,观察组精子PR高于对照组(P<0.05).②治疗3个月后,观察组精子DFI较治疗前显著下降(P<0.01).③治疗3个月后,观察组总有效率高于对照组[86.7%(26/30)vs 63.3%(19/30),P<0.05].结论:麦粒灸结合药物治疗对精子浓度和精子前向活率有较好的改善作用,可以提高精子DNA完整性.

Objective To observe the clinical effect of grain-moxibustion combined with medicine therapy for asthenospermia and oligospermia. Methods A tatal of 60 patients were randomized into an observation group(30 cases) and a control group(30 cases) according to 1︰1 ratio. In the control group, vitamin E capsules were taken orally one capsule each time, twice a day, and Wuzi Yanzong pills 6 g each time, three times a day for a total of 3 months. In the observation group, grain-moxibustion was applied at Guanyuan(CV 4),Shenshu(BL 23) and Zusanli(ST 36) based on the control group, once a week for 3 months, with a total of 12 times. The sperm concentration and sperm progressive motility were measured by automatic sperm quality analysis system in the two groups, and the clinical effects were compared. Sperm DNA fragmentation index(DFI) in the observation group was measured by sperm nucleus chromosome structure assay(SCSA). Results(1)The sperm concentrations and sperm progressive motilities after 1-month, 2-month and 3-month of treatment were increased compared with those before treatment in the two groups(P<0.01), and they were increased with time. In the two groups, 2-month and 1-month of treatment, 3-month and 2-month of treatment were compared, the sperm concentrations and sperm progressive motilities were significantly increased(P<0.01). The sperm concentrations after 1-month, 2-month and 3-month of treatment in the observation group were higher than those in the control group(P<0.01), the sperm progressive motility after 3-month of treatment in the observation group was higher than that in the control group(P<0.05).(2)After 3-month of treatment,the DFI in the observation group was significantly reduced compared with that before treatment(P<0.01).(3)The total effective rate in the observation group after 3-month of treatment was 86.7%(26/30), which was superior to 63.3%(19/30) in the control group(P<0.05). Conclusion Grain-moxibustion combined with medicine therapy can improve sperm concentration and sperm progressive motility, enhance the integrity of sperm DNA.