靶向星形胶质细胞治疗缺血性脑卒中的研究进展

The research on regulating astrocyte protection function after ischemic stroke

缺血性脑卒中(ischemic stroke, IS)发生后,缺血区星形胶质细胞(astrocyte)活化,这些反应性星形胶质细胞对缺血区神经元发挥有利和有害双重作用。星形胶质细胞与IS诱导的谷氨酸功能障碍、线粒体功能障碍和胶质瘢痕形成密切相关,并且在IS后神经元网络重构中发挥重要调节作用。现重点探讨如何利用星形胶质细胞对IS发挥保护作用的研究进展。

Astrocytes are activated after ischemic stroke(IS). The astrocytes play both deleterious and beneficial roles in ischemic area. Astrocytes are involved in extracellular glutamate dysfunction, mitochondrial dysfunction and glial scar formation, and play an important regulatory role in neuronal network remodeling after IS. In this review, we will focus on the recent progresses regarding to the protection function of astrocytes in IS.