锌代谢与食管癌关系的研究进展

Progress in the relationship between zinc metabolism and esophageal cancer

食管癌是我国常见的恶性肿瘤之一,虽然目前采取多学科综合治疗,但预后仍较差。食管癌的发生与微量元素锌的代谢密切相关,缺锌可以通过诱导炎症反应、microRNAs失调导致食管癌的发生与发展,锌离子可通过调节离子通道的活性在食管癌中发挥重要作用,锌离子参与形成的锌指蛋白在食管癌中可发挥致癌基因或抑癌基因的作用。锌代谢在食管癌的发病过程伴随着复杂的生物学变化,多个机制间相互作用,联系紧密。本文将围绕缺锌、锌离子调节离子通道、锌指蛋白在食管癌发生与发展中的机制就近年来的研究成果进行综述。

Esophageal cancer is one of the common malignant tumors in China. Although it is currently treated by multidisciplinary treatment, esophageal cancer′s prognosis is still poor. The occurrence of esophageal cancer is closely related to the metabolism of trace element zinc. Zinc deficiency can induce the development of esophageal cancer by inducing inflammatory reaction and microRNAs imbalance. Zinc ion can play an important role in esophageal cancer by regulating the activity of ion channel. The formed zinc finger protein can function as an oncogene or a tumor suppressor gene in esophageal cancer. Zinc metabolism is accompanied by complex biological changes in the pathogenesis of esophageal cancer, and multiple mechanisms interact and are closely linked.The article reviews the research results of recent years on the mechanism of zinc deficiency, zinc ion-regulated ion channel and zinc finger protein in the development of esophageal cancer.