低分子肝素治疗复发性流产患者血管相关因子表达观测

Observation of Vascular Related Factors Expression in Patients with Recurrent Spontaneous Abortion Treated with Low Molecular Weight Heparin

目的研究低分子肝素治疗复发性流产患者血管相关因子表达。方法 2017年6月-2018年8月间方便选择复发性流产患者作为该次研究对象,并采用"电脑随机法"将100例复发性流产患者进行分组,主要包括两组,其中观察组、实施低分子肝素治疗;对照组、实施传统保胎治疗,分析两组治疗效果、血管相关因子表达以及不良反应情况。结果观察组复发性流产患者治疗总有效率高于对照组,两者差异有统计学意义(χ^2=10.714,P<0.05)。观察组复发性流产患者mRNA中TLR4(23.11±1.21)、NF-kB p65(39.65±1.54)均低于对照组;蛋白中TLR4(132.21±1.54)、NF-kB p65(139.55±1.54)均高于对照组,差异有统计学意义(t=76.254、62.961、90.385、77.083,P<0.05)。观察组复发性流产患者不良反应发生率2.00%低于对照组,差异有统计学意义(χ^2=10.699,P<0.05)。结论低分子肝素治疗复发性流产患者效果显著,能够降低其血管相关因子表达,值得研究。

Objective To study the expression of vascular related factors in patients with recurrent spontaneous abortion treated with low molecular weight heparin. Methods From June 2017 to August 2018 patients with recurrent spontaneous abortion were convenient selected as the study patients or subjects. 100 patients with recurrent spontaneous abortion were divided into two groups, including the observation group and low molecular weight heparin treatment. The traditional treatment of fetal miscarriage was carried out, and the therapeutic effects, the expression of vascular related factors and the adverse reactions were analyzed. Results The total effective rate of the patients with recurrent spontaneous abortion in the observation group was higher than that in the control group(χ^2=10.714,P<0.05). The difference was statistically significant.The TLR4(23.11±1.21) and NF-kB p65(39.65±1.54) in the recurrent spontaneous abortion patients in the observation group were lower than those in the control group;the TLR4(132.21±1.54) and NF-kB p65(139.55±1.54) were high in the protein. In the control group, the difference was statistically significant(t=76.254, 62.961, 90.385, 77.083, P<0.05). The incidence of adverse reactions in the observation group was 2.00% lower than that in the control group, and the difference was statistically significant(χ^2=10.699, P<0.05). Conclusion Low molecular weight heparin is effective in the treatment of patients with recurrent spontaneous abortion and can reduce the expression of vascular related factors. It is worthy of study.