下呼吸道感染疾病采用不同抗生素方案治疗的药学效果对比分析

Comparative Analysis of Pharmacological Effects of Different Antibiotic Regimens for Lower Respiratory Tract Infections

目的评价不同抗生素方案治疗下呼吸道感染疾病的药学效果。方法将该院2016年10月—2017年10月收治的160例下呼吸道感染疾病患者随机分为观察1组、观察2组、观察3组、观察4组,予以观察1组头孢曲松钠治疗,予以观察2组阿奇霉素治疗,予以观察3组头孢噻肟钠治疗,予以观察4组左氧氟沙星治疗,治疗周期均为1周,比较4组整体治疗效果、不良反应发生情况、治疗费用。结果观察1组、观察2组、观察3组、观察4组临床治疗总有效率分别为92.50%、95.00%、90.00%、92.50%,不良反应发生率分别为7.50%、7.50%、5.00%、5.00%,组间均差异无统计学意义(χ^2=0.079、0.251,P>0.05),观察1组的治疗费用为(596.67±45.88)元,与观察4组的(588.91±48.03)元比较差异无统计学意义(P>0.05),明显低于观察2组的(814.70±50.83)元和观察3组的(831.35±54.05)元(F=7.152,P<0.05)。结论头孢曲松钠、阿奇霉素、头孢噻肟钠、左氧氟沙星用于治疗下呼吸道感染疾病均能获得良好疗效,且不良反应较少,但头孢曲松钠和左氧氟沙星更加经济,推广应用优势更加明显。

Objective To evaluate the pharmacological effects of different antibiotic regimens in the treatment of lower respiratory tract infections. Methods 160 patients with lower respiratory tract infections admitted to our hospital from October 2016 to October 2017 were randomly divided into observation group 1, observation group 2, observation group 3, observation group 4, and observation group 1 adopted ceftriaxone sodium. Observation group 2 of azithromycin treatment, observation group 3 of cefotaxime sodium, and observation group 4 of levofloxacin. The treatment period was 1 week. The overall treatment effect, adverse reaction and treatment cost of the four groups were compared. Results The total effective rates of clinical treatment were 92.50%, 95.00%, 90.00%, and 92.50%, respectively, and the incidence of adverse reactions were 7.50%, 7.50%, and 5.00%, 5.00%, the difference between the groups was not statistically significant (χ^2=0.079, 0.251, P>0.05), the treatment cost of observation group 1 was (596.67±45.88) yuan, and the observation group 4 (588.91±48.03) yuan. There was no statistically significant difference (P>0.05), which was significantly lower than that of the observation group (814.70±50.83)yuan and the observation group 3 (831.35±54.05)yuan (F=7.152, P<0.05). Conclusion Ceftriaxone sodium, azithromycin, cefotaxime sodium and levofloxacin are effective in the treatment of lower respiratory tract infections, and the adverse reactions are less, but ceftriaxone sodium and levofloxacin are more economical, and the advantages of promotion and application are more obvious.