探讨硫酸镁联合拉贝洛尔治疗妊娠期高血压疾病的临床疗效

Exploring the Clinical Efficacy of Magnesium Sulfate Combined with Labetalol in the Treatment of Hypertensive Disorder Complicating Pregnancy

目的评价硫酸镁联合拉贝洛尔治疗妊娠期高血压疾病(HDCP)的疗效。方法研究时间以2017年7月—2019年1月为准,回顾该时间段内该院收治的66例HDCP孕妇治疗情况。根据治疗药物不同分为对照组和研究组,其中对照组患者单纯应用硫酸镁治疗,研究组患者应用硫酸镁联合使用拉贝洛尔治疗。对比两组患者的治疗效果、不良反应情况及妊娠结局。结果研究组治疗总有效率96.97%高于对照组的81.82%,差异有统计学意义(χ^2=3.9952,P<0.05);研究组和对照组不良反应发生率分别为15.15%、6.06%,两组比较差异无统计学意义(χ^2=1.4382,P>0.05);妊娠结束时,除产后出血率外,研究组剖宫产率、胎儿宫内窘迫率、新生儿低血压、新生儿窒息等妊娠结局均少于对照组(χ^2=3.8824、4.2581、5.1207、3.9952,P<0.05)。结论应用硫酸镁联合拉贝洛尔治疗妊娠期高血压疾病可取得较好的效果,且联合使用不会增加不良反应,还能显著改善妊娠结局,值得推广。

Objective To evaluate the efficacy of magnesium sulfate combined with labetalol in the treatment of hypertensive disorder complicating pregnancy (HDCP). Methods The study time was from July 2017 to January 2019. We reviewed the treatment of 66 cases of HDCP pregnant women admitted to our hospital during this time period. According to the different treatment drugs, the patients were divided into the control group and the study group. The control group was treated with magnesium sulfate alone. The patients in the study group were treated with magnesium sulfate combined with labetalol. The treatment effects, adverse reactions and pregnancy outcomes of the two groups were compared. Results The total effective rate of the study group was 96.97% higher than that of the control group (81.82%). The difference was statistically significant (χ^2=3.995 2, P<0.05). The incidence of adverse reactions in the study group and the control group were 15.15% and 6.06%, respectively. There was no statistically significant difference between the two groups (χ^2=1.438 2, P>0.05). At the end of pregnancy, in addition to the postpartum hemorrhage rate, the study group had cesarean section rate, intrauterine distress rate, neonatal hypotension, neonatal asphyxia and other pregnancy outcomes were less than the control group (χ^2=3.882 4,4.258 1,5.120 7,3.995 2, P<0.05). Conclusion The application of magnesium sulfate combined with labetalol in the treatment of hypertensive disorder complicating pregnancy can achieve better results, and the combined use will not increase the adverse reactions, but also significantly improve the pregnancy outcome, which is worth promoting.