体外循环代谢性酸中毒补碱的一个新公式

A new formula for calculation of the amount of alkali in patients with metabolic acidosis during cardiopulmonary bypass

目的本研究旨在探讨心肺转流(CPB)术中代谢性酸中毒补碱的一个新公式。方法根据传统公式,加上预充液量导出新公式。前瞻性分析2017年10月至12月在北京安贞医院接受CPB手术的成人40例患者,分为传统公式组和新公式组,每组20例。结果所有患者均存活出院。新公式组补碱10min后pH比传统公式稍高[(7.39±0.05)vs.(7.36±0.03),P=0.01]。另外,新公式组首次补碱后pH及BE恢复正常的患者比例较传统公式组高,但差异无统计学意义(90%vs.70%,P=0.11;85%vs.65%,P=0.14)。结论新公式似乎能更准确的计算出所需碱量,使患者更快地恢复正常的酸碱状态。

Objective The aim of this study was to introduce a new formula for calculation of the amount of alkali in patients with metabolic acidosis during cardiopulmonary bypass (CPB).Methods The new formula was based on the old formula.Between October and December 2013,40 CPB patients with metabolic acidosis were evaluated prospectively and divided into two groups:the new formula group and the old formula group.Results All of the patients survived to hospital discharge.At 10 min after infusion of 5% NaHCO3,pH value was higher in the new formula group than in the old formula group (7.39±0.05 vs.7.36±0.03,P=0.01).More patients were of normal pH value or base excess in the new formula group than that in the old formula group,but no significant difference was observed (90% vs.70%,P =0.11;85% vs.65%,P =0.14).Conclusion The new formula seems to be more accurate in calculating the amount of alkali in patients with metabolic acidosis during CPB.