摘要
结直肠癌是全球高发恶性肿瘤之一,严重威胁人类健康。肝转移是造成结直肠癌患者死亡的最主要原因,但其发生机制尚不明确。我们以结直肠癌发生肝转移的关键步骤为主线,综合分析了参与调控该过程的相关基因和信号通路,试图为探索结直肠癌肝转移治疗提供新的思路和理论基础。
Colorectal cancer is one of the most prevalent malignances worldwide and represents a significant burden to public health. Liver metastasis is the main cause of colorectal cancer-related death and its mechanism is still unknown. In this review,we follow the key steps of liver metastasis in colorectal cancer, analyze the related genes and signaling pathways that are involved in modulating these steps so as to provide theoretical foundation for and novel insightinto the treatment of liver metastasis in colorectal cancer.
作者
韩凯
王凤伟
潘志忠
谢丹
Han Kai;Wang Fengwei;Pan Zhizhong;Xie Dan(State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou 510060, Guangdong, China;Department of Colorectal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou 510060, Guangdong, China)
出处
《结直肠肛门外科》
2019年第4期390-393,405,共5页
Journal of Colorectal & Anal Surgery
关键词
结直肠癌
肝转移
分子机制
种子和土壤学说
colorectal cancer
liver metastasis
molecular mechanism
seed and soil hypothesis
