低剂量罗哌卡因复合不同剂量分娩的效果分析

Effect Analysis of Low Dose Ropivacaine Combined with Different Dose of Delivery

目的探讨低剂量罗哌卡因复合不同剂量舒芬太尼硬膜外给药在分娩镇痛中的应用效果。方法选择2017年1月—2018年6月于本院待产的产妇60例,采用随机数字表法将产妇分为I组(n=30)与Ⅱ组(n=30),Ⅰ组予以0.08%罗哌卡因复合0.2 ug/ml舒芬太尼硬膜外镇痛,Ⅱ组予以0.08%罗哌卡因复合0.4 ug/ml舒芬太尼硬膜外镇痛,比较两组镇痛效果。结果Ⅱ组产妇T1、T2、T3时的血清SP、β-EP、NPY水平低于I组(P <0.05)。Ⅱ组产妇T1、T2、T3时的NRS评分低于Ⅰ组(P <0.05)。Ⅱ组产妇的镇痛起效时间短于Ⅰ组,镇痛维持时间、总镇痛时间长于Ⅰ组,第一产程短于Ⅰ组(P <0.05)。结论低剂量罗哌卡因复合0.4 ug/ml舒芬太尼硬膜外麻醉可有效抑制疼痛递质表达,镇痛起效快,持续时间长,可减轻产妇的分娩疼痛,缩短产程。

Objective To investigate the effect of low-dose ropivacaine combined with different doses of sufentanil epidural administration in labor analgesia. Methods Sixty parturients waiting for delivery in our hospital from January 2017 to June 2018 were divided into group I (n=30) and group Ⅱ(n=30) by random number table. Group I received 0.08% ropivacaine combined with 0.2 ug/ml sufentanil epidural analgesia, and group Ⅱ received 0.08% ropivacaine combined with 0.4 ug/ml sufentanil epidural analgesia. The analgesic effect was compared between the two groups. Results Serum levels of SP, beta-ep and NPY were significantly lower in group Ⅱ than in group Ⅰ at the time of , T1, T2 and T3 (P<0.05). The NRS scores of women in group Ⅱ at, T1, T2 and T3 were significantly lower than those in group Ⅰ(P<0.05).The onset time of analgesia in group Ⅱ was significantly shorter than that in group Ⅰ, the duration of analgesia maintenance and total analgesia duration were significantly longer than that in group Ⅰ, and the first labor stage was significantly shorter than that in group Ⅰ(P<0.05). Conclusion Low-dose ropivacaine combined with 0.4ug/ml sufentanil epidural anesthesia can effectively inhibit the expression of pain transmitter, the analgesic effect is rapid, the duration is long, can reduce maternal pain during labor, shorten the length of labor, it is recommended.