帕罗西汀联合团体心理治疗焦虑障碍伴糖调节受损患者的临床疗效及对生命质量的影响

Clinical efficacy of paroxetine combined with group psychotherapy in patients with anxiety disorder complicated with impaired glucose regulation and its impact on quality of life

目的探讨帕罗西汀联合团体心理治疗焦虑障碍伴糖调节受损患者的临床疗效及对生命质量的影响。方法选择我院2017年3月~2018年9月收治的焦虑障碍伴糖调节受损患者105例,随机分为观察组(n=53)和对照组(n=52)。两组均给予盐酸帕罗西汀治疗,观察组在对照组的基础上联合团体心理治疗。观察比较两组HAMA评分、FPG水平、2 hPPG水平及SF-36评分。结果治疗后,两组HAMA评分均显著降低(t=13.125,P=0.000;t=11.380,P=0.000);且观察组HAMA评分[(14.34±5.01)分]显著低于对照组[(16.22±4.62)分](t=-1.988,P=0.048)。治疗后,观察组FPG水平、2 hPPG水平均显著降低(t=2.130,P=0.036;t=4.335,P=0.000),且均低于对照组(t=-2.043,P=0.044;t=-4.115,P=0.000)。治疗后,两组SF-36评分均显著升高(t=-6.404,P=0.000;t=-4.302,P=0.000);且治疗后观察组SF-36评分[(81.45±21.06)分]显著高于对照组[(73.52±18.59)分](t=2.047,P=0.043)。结论帕罗西汀联合团体心理治疗焦虑障碍伴糖调节受损临床疗效显著,可有效缓解患者焦虑情绪,降低机体血糖,提高患者生活质量,值得推广应用。

Objective To investigate the clinical efficacy of paroxetine combined with group psychotherapy in the treatment of patients with anxiety disorder complicated with impaired glucose regulation and its impact on quality of life.Methods A total of 105 patients who were admitted to our hospital from March 2017 to September 2018 were selected and randomly divided into observation group(n=53) and control group(n=52).Both groups were given paroxetine hydrochloride for treatment.The observation group was combined with group psychotherapy on the basis of the control group.The HAMA score,FPG level,2 hPPG level and SF-36 score were observed and compared between the two groups.Results After treatment,the HAMA scores in both groups were significantly reduced(t=13.125,P=0.000;t=11.380,P=0.000);the HAMA score was(14.34±5.01) scores in the observation group,which was significantly lower than that of(16.22±4.62) scores in the control group(t=-1.988,P=0.048).After treatment,the FPG level and 2 hPPG level in the observation group were significantly lower(t=2.130,P=0.036;t=4.335,P=0.000);they were all lower than those in the control group(t=-2.043,P=0.044;t=-4.115,P=0.000).After treatment,the SF-36 scores in both groups were significantly increased(t=-6.404,P=0.000;t=-4.302,P=0.000);the score of SF-36 in the observation group was(81.45±21.06),which was significantly higher than that of(73.52±18.59) in the control group(t=2.047,P=0.043).Conclusion Paroxetine combined with group psychotherapy in the treatment of anxiety disorder complicated with impaired glucose regulation has a significant clinical effect,which can effectively alleviate patients' anxiety,reduce blood sugar and improve patients' quality of life.It is worthy of popularization and application.