骨架铜催化的烷氧基位阻胺还原胺化反应研究

Research on the Reductive Amination of 1-alkoxy Hindered Amine with Skeleton Copper as Catalyst

论文研究了1-烷氧基位阻胺对位二胺化合物的制备。以骨架铜为催化剂,1-烷氧基-2,2,2,6,6-四甲基哌啶-4-酮与己二胺在高压釜中发生直接还原胺化反应得到目标化合物。重点探讨了催化剂用量、反应压力、反应温度对还原胺化反应的影响。

The preparation of 1-alkoxy hindered amine para-diamine derivatives were researched in this paper.Using skeleton copper as catalyst, 1-alkoxy-2,2,2,6,6-tetramethylpiperidin-4-one and hexamethylenediamine were subjected to a direct reductive amination process in autoclave to gave the target compound.The effects of catalyst dosage, reaction pressure and reaction temperature on reductive amination were discussed.