雌激素联用宫缩剂对宫缩乏力性产后出血疗效及安全性分析

Efficacy and safety of estrogen combined with oxytocin in treatment of postpartum hemorrhage due to uterine atony

目的探讨雌激素联用宫缩剂对宫缩乏力性产后出血疗效及安全性分析。方法将2016年2月~2019年2月在妇产科治疗的80例宫缩乏力性产后出血患者随机分为两组,对照组单用缩宫素治疗,观察组给予雌激素与宫缩剂联用,比较两组患者的临床疗效、产后出血量、预后、不良反应。结果观察组治疗总有效率为95%,明显高于对照组的70%(P<0.05);观察组治疗后2h内出血量、2~24h内出血量明显少于对照组(P<0.05);观察组子宫切除率、死亡率明显低于对照组(P<0.05);观察组恶心呕吐、头痛、胸闷、乳房胀痛等不良反应发生率明显低于对照组(P<0.05)。结论雌激素联用宫缩剂对宫缩乏力性产后出血疗效显著,能有效增强子宫收缩,减少产后出血量,改善预后,且不良反应发生率低,具有较高的有效性及安全性。

Objective To investigate the efficacy and safety of estrogen combined with oxytocin in the treatment of postpartum hemorrhage due to uterine atony.Methods 80 cases of postpartum hemorrhage due to uterine inertia were randomly divided into two groups from February 2016 to February 2019.The control group was treated with oxytocin alone,while the observation group was treated with estrogen combined with uterine contraction agents.The clinical efficacy,postpartum hemorrhage volume,prognosis and adverse reactions of the two groups were compared.Results The effective rate of the observation group was 95%,which was significantly higher than 70%of the control group(P<0.05);the amount of bleeding within 2 hours and 2~24 hours after treatment in the observation group was significantly less than that in the control group(P<0.05);the rate of hysterectomy and mortality in the observation group were significantly lower than those in the control group(P<0.05);the incidence of adverse reactions such as nausea,vomiting,headache,chest distress and breast distention in the observation group was significantly lower(P<0.05).Conclusion The combination of estrogen and uterine contraction agent has a significant effect on postpartum hemorrhage caused by uterine inertia.It can effectively enhance uterine contraction,reduce postpartum hemorrhage and improve prognosis.The incidence of adverse reactions is low,and it has high effectiveness and safety.