清肺化瘀汤辅助治疗儿童大叶性支原体肺炎临床疗效观察

Clinical observation of Qingfei Huayu decoction assisting the treatment of children with large lobar pneumonia

目的探究与分析中西医结合治疗儿童大叶肺炎的临床疗效观察。方法选择2016年3月至2018年3月山东省巨野县人民医院儿科收治的肺炎支原体感染引起的大叶性肺炎患儿95例,随机分为观察组48例和对照组47例。对照组给予阿奇霉素治疗,观察组在对照组治疗基础上给予中药自拟方清肺化瘀汤治疗。两组均连续治疗10d。观察两组患儿临床疗效、症状体征消失时间、肺功能指标和不良反应。结果观察组总有效率为95.8%(46/47),显著高于对照组80.9%(38/47),差异有统计学意义(P<0.05)。观察组发热持续时间、咳嗽持续时间、肺部啰音消失时间、影像学指征恢复正常时间均短于对照组,差异有统计学意义(P<0.05)。两组治疗后每公斤体质量的潮气量、达峰时间比、达峰容积比水平显著高于治疗前,观察组治疗后上述指标显著高于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率为6.25%(3/48),显著低于对照组21.28%(10/47),差异有统计学意义(P<0.05)。结论中西医结合治疗儿童大叶肺炎临床疗效确切,能够加快症状体征消失时间,且安全性高。

Objective To investigate and analyze the clinical efficacy of integrated Chinese and western medicine in the treatment of children with large lobar pneumonia.Methods A total of 95 children with lobar pneumonia admitted to our hospital from January 2017 to January 2019 were randomly divided into two groups.Forty-eight patients in the treatment group were given the self-made prescription of Qingfei Huayu decoction combined with azithromycin.In the control group,47 patients received azithromycin.The treatment lasted for 10 days.The clinical efficacy,time for symptoms and signs to disappear,lung function index,and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 95.8%(46/47),which was significantly higher than that of the control group(80.9%,38/47).The difference was statistically significant(P<0.05).Compared with the control group,the duration of fever,the duration of cough,the recovery time of lung rales,and the time for imaging signs to return to normal were shorter in the observation group.The difference was statistically significant(P<0.05).The Vt/kg,TPTEF/TE and VTEEF/VE levels of both groups were significantly higher after treatment than before treatment,and these indexes in observation group were significantly higher,the difference being of statistical significance(P<0.05).The incidence of adverse reactions was significantly lower in the observation group than in the control group,and the difference was statistically significant(P<0.05).Conclusion The clinical efficacy of integrated Chinese and western medicine has good clinical effect in the treatment of children with large lobar pneumonia,which can speed up the disappearance of symptoms and has high safety.