氟桂利嗪联合氟哌噻吨美利曲辛治疗椎动脉型颈椎病伴焦虑患者的疗效

Efficacy of Flunarizine Combined with Flupentixol and Melitracen in the Treatment of Vertebral Artery Type Cervical Spondylosis with Anxiety

目的椎动脉型颈椎病伴发焦虑患者应用氟桂利嗪与氟哌噻吨美利曲辛联合治疗效果分析。方法选取2017年1月-2017年9月本院诊治的椎动脉型颈椎病伴发焦虑72例患者资料,按照随机数字表方法分两组,对照组予氟桂利嗪,研究组予氟桂利嗪与氟哌噻吨美利曲辛联合方案,分析两组眩晕、疼痛指标及心理状态、不良反应情况。结果治疗后,两组评分均降低,且研究组眩晕程度(1.19±0.42)分、眩晕频率(1.08±0.39)分、持续时间(1.12±0.38)分及疼痛指标(2.15±0.64)分,均比对照组少,比较差异具统计意义(P<0.05);研究组SAS(32.23±9.46)分、SDS(33.03±9.46)分均比对照组少,差异比较具统计意义(P<0.05);两组均无严重不良反应,比较无差异(P>0.05)。结论椎动脉型颈椎病伴发焦虑患者应用氟桂利嗪与氟哌噻吨美利曲辛联合方案,能改善患者眩晕、疼痛指标,并能缓解其负面心理状态,具用药安全性。

Objective To analyze the effect of flunarizine combined with flupentixol and melitracen in patients with vertebral artery type cervical spondylosis with anxiety. Methods A total of 72 patients with vertebral artery type cervical spondylosis who were diagnosed and treated in our hospital from January 2017 to September 2017 were enrolled. The patients were divided into two groups according to the random number table. The control group was given flunarizine. The study group was taken the combination of cinnarizine and flupentixol treatment. Then analyzed the vertigo, pain index, psychological state and adverse reactions between two group. Results After treatment, the scores of both groups were reduced, and the degree of vertigo (1.19±0.42), vertigo frequency (1.08±0.39), duration (1.12±0.38) and pain index (2.15±0.64) in the study group were lower than the control group, the differences were statistically significant (P<0.05). The SAS (32.23±9.46) and SDS (33.03±9.46) scores in the study group were lower than in the control group, and the difference was statistically significant (P<0.05). There were no serious adverse reactions in the two groups, and there was no difference (P>0.05). Conclusion The combination of flunarizine and flupentixol and melitracen in patients with vertebral artery type cervical spondylosis with anxiety could improve the patient's dizziness and pain index, and also could alleviate their negative psychological state.