社区中老年慢性病患者血清同型半胱氨酸的水平及影响因素分析

Levels of serum homocysteine in middle-aged and elderly patients with chronic illness in community and their influence factors

目的探讨北京市通州区中老年慢性病患者血清同型半胱氨酸(Hcy)水平及其影响因素.方法选取通州社区≥55岁的慢性病患者467例,被调查对象均完成问卷调查及实验室检查,检测血清Hcy、肌酐(Cr)、尿酸(UA)、血糖(Glu)等水平.按照被调查对象是否存在高同型半胱氨酸血症(Hcy>15μmol/L)将其分为两组.结果 Hcy升高组的Cr、UA、尿素氮(BUN)水平高于Hcy正常组,差异有统计学意义(P<0.05).采用Pearson相关分析显示:血清Hcy与Cr(r=0.436,P=0.000)、UA(r=0.282,P=0.000)、BUN(r=0.311,P=0.000)呈正相关.结论男性、吸烟、饮酒、饮茶、Cr、UA、BUN异常是导致中老年人高Hcy血症的危险因素.

Objective To investigate the influence factors for the levels of serum homocysteine (Hcy) in middle-aged and elderly patients with chronic illness in Tongzhou community of Beijing. Methods A total of 467 patients with chronic illness ≥ 55 years old were enrolled from Tongzhou community. All participants were asked to complete a standardized questionnaire and laboratory examinations. Their serum Hcy, creatinine (Cr), uric acid (UA), glucose (Glu) and so on were determined. The participants were divided into two groups according to serum level of Hcy with a cutpoint of 15 μmol/L. Results The participants with hyperhomocysteinemia had higher levels of creatinine (Cr), uric acid (UA) and urea nitrogen (BUN) than those with normal level of serum Hcy (P<0.05). Pearson correlation analysis showed that serum Hcy was positively correlated with Cr (r= 0.436, P=0.000), UA (r=0.282, P=0.000) and BUN (r=0.311, P=0.000). Conclusion Men, smoking, drinking alcohol, drinking tea, abnormal Cr, UA and BUN are risk factors for high Hcy in middle and old aged people.