不同类型玫瑰痤疮与幽门螺杆菌相关研究及临床疗效观察

Study on the relationship between different types of rosacea and Helicobacter pylori and clinical efficacy

目的检测不同类型玫瑰痤疮患者幽门螺杆菌(HP)感染率,观察盐酸米诺环素(MINO-HCL)联合红蓝光照射治疗该病的临床疗效。方法将172例玫瑰痤疮患者分为红斑毛细血管扩张型(A组)62例、丘疹脓疱型(B组)60例、肥厚增生型(C组)50例。所有患者均予 14 C呼气试验检测HP感染率。将每型患者再分为治疗组(口服MINO-HCL和红蓝光照射)和对照组(仅口服MINO-HCL),1个月后观察皮损消退情况。结果丘疹脓疱型和肥厚增生型患者HP阳性率明显高于红斑毛细血管扩张型。红斑毛细血管扩张型和丘疹脓疱型患者HP转阴率均明显高于肥厚增生型患者。红斑毛细血管扩张型和丘疹脓疱型患者治疗组显效率高于对照组,治疗组中红斑毛细血管扩张型和丘疹脓疱型患者显效率高于肥厚增生型患者。结论 HP感染可能是玫瑰痤疮丘疹脓疱型患者的重要发病因素,口服MINO-HCL和红蓝光照射联合治疗对红斑毛细血管扩张型和丘疹脓疱型患者疗效高,副作用小,值得在临床上推广。

Objective To test the infection rate of Helicobacter pylori(HP) in patients with different types of rosacea and investigate the clinical efficacy of minocyline hydrochloride capsules combined with red-blue light irradiation. Methods A total of 172 patients with rosacea were divided into three groups: erythema and angiotelectasis type 62(group A), papulopustule type 60(group B), hypertrophic hyperplasia type 50(group C). All the patients were detected with 14C urea breath test. Three group patients were randomly divided into two groups again. The treatment group was received minocyline hydrochloride capsules combined with red-blue light irradiation and the control group received oral capsules only. The improvement in skin lesions was observed one month later. Results The infection rate of HP in group B and C patients was higher than that in group A. The negative conversion rate of HP in group A and B patients was higher than that in group C. In group A and group B patients, the apparent efficiency of the treatment group was higher than the control group. In all of the treatment group, the apparent efficiency of group A and B patients was higher than that in group C. Conclusion HP infection might be a significant cause of papulopustule type rosacea. Oral minocyline hydrochloride combined with red-blue light irradiation has a good synergistic effect in the former two types rosacea. It is worth promoting on clinical.