HHIP基因rs13118928单核苷酸多态性与慢性阻塞性肺疾病易感性的荟萃分析

Meta-analysis on relationship between HHIP rs13118928 single nucleotide polymorphism and susceptibility to chronic obstructive pulmonary disease

目的探讨Hedgehog相互作用蛋白(HHIP)基因rs13118928位点单核苷酸多态性与慢性阻塞性肺疾病(COPD)易感性的关联。方法系统检索PubMed、EMBASE、Web of Science、中国知网和万方五个电子数据库。检索时间为建库到2018年1月5日,根据制定的纳入标准筛选出相关研究文章,提取数据后利用RevMan5.3软件进行统计分析,计算出各种遗传模型下的比值比(OR)和95%的可信区间(95%CI)。结果本项研究共纳入7篇文献,包括5157个COPD患者和9768个健康对照者。荟萃分析结果显示HHIP基因rs13118928多态性在五种遗传模型下均与COPD有显著相关性:Avs.G,OR=1.14,95%CI,1.08~1.20,P<0.001;AAvs.GG,OR=1.36,95%CI,1.20~1.55,P<0.001;AGvs.GG,OR=1.27,95%CI,1.03~1.58,P=0.030;AA+AGvs.GG,OR=1.31,95%CI,1.10~1.57,P=0.003;AAvs.AG+GG,OR=1.12,95%CI,1.04~1.21,P=0.002。亚组分析结果显示在亚洲人种和高加索人种中,rs13118928多态性在Avs.G和AAvs.GG遗传模型下与COPD的发生有显著相关性。结论HHIP基因rs13118928单核苷酸多态性与COPD的发生有显著相关性。A等位基因和AA基因型携带者对COPD有较高的易感性。

Objective To explore whether the HHIP rs13118928 single nucleotide polymorphism (SNP) is associated with the susceptibility to chronic obstructive pulmonary disease (COPD).Methods Based on our inclusion criteria,a systematic search of the relevant studies from the construction of the database until January 5,2018 was conducted using the PubMed,EMBASE,Web of Science,CNKI and Wanfang databases.Meta-analysis was performed with RevMan 5.3 software.Summary odds ratios ( ORs ) and 95% confidence intervals ( CIs ) were estimated under allelic and genotypic comparisons.Results Seven reports containing 5 157 COPD patients and 9768 controls met the inclusion criteria.The results suggested a significant relationship between HHIP rs13118928 SNP and COPD susceptibility (A vs.G,OR =1.14,95% CI,1.08- 1.20,P <0.001;AA vs.GG,OR =1.36,95% CI,1.20-1.55,P <0.001;AG vs.GG;OR =1.27,95% CI,1.03-1.58,P =0.030;AA+AG vs.GG,OR =1.31,95% CI,1.10-1.57,P =0.003;AA vs.AG+GG,OR =1.12,95% CI,1.04-1.21,P =0.002).Subgroup analysis by ethnicity indicated that there existed a significant relationship between rs13118928 SNP and the occurrence of COPD under A vs.G and AA vs.GG models in both Asian and Caucasian population.Conclusion The present meta-analysis suggests that HHIP rs13118928 SNP is significantly related with COPD susceptibility.