表面等离子体处理共聚接枝改性对热塑性聚氨酯(TPU)的生物学性能影响研究

Study on the Effect of Surface Plasma Treatment Copolymerization Graft Modification on the Biological Properties of Thermoplastic Polyurethane(TPU)

通过在热塑性聚氨酯(TPU)表面接枝甲基丙烯酸-2-羟基乙酯(HEMA)、甲基丙烯酸缩水甘油酯(GMA),以提高材料的生物相容性。研究了单体接枝与共聚接枝对TPU性能的影响,凸显出了共聚接枝工艺的优越性。通过傅里叶红外光谱、扫描电子显微镜、EDS能谱分析、接触角分析,对改性后的材料表面进行表征。利用拉伸测试分析接枝工艺对材料力学性能的影响。进行细胞毒测试、溶血率测试,研究材料改性后的生物学性能变化。实验结果表明,共聚接枝具有比单体接枝更优良的改性效果。改性后的TPU,保持了原样优异的拉伸性能,延展性提高了50%,生物相容性得到良好改善。共聚接枝工艺极大增加了材料表面的活性基团和亲水性,从而降低了材料的细胞毒性和溶血率。

In this study,2-hydroxyethyl methacrylate(HEMA)and glycidyl methacrylate(GMA)were grafted on the surface of thermoplastic polyurethane(TPU)to improve the biocompatibility of the material.The effects of monomer grafting and copolymer grafting on the properties of TPU were studied,which highlighted the superiority of the copolymer grafting process.The surface of the modified material was characterized by fourier transform infrared spectroscopy,scanning electron microscopy,energy dispersive spectrometer analysis and contact angle analysis.The tensile test was used to analyze the effect of the grafting process on the mechanical properties of the material.The cytotoxicity test and hemolysis rate test were used to study the biological properties of the material after modification.The experimental results show that the copolymer grafting has better modification effects than the monomer grafting.The modified TPU maintains the excellent tensile properties as the original sample,the ductility could increase 50%,and the biocompatibility has been improved significantly.The copolymerization grafting process greatly increases the reactive groups and hydrophilicity of the surface of the material,thereby reducing the cytotoxicity and hemolysis rate of the material.