炎症在慢性脑低灌注引起的认知损害中的作用及其机制

Role of inflammation in cognitive impairment induced by chronic cerebral hypoperfusion and its mechanism

慢性脑低灌注(chronic cerebral hypoperfusion, CCH)是中枢神经系统疾病共有的病理改变,与认知损害密切相关。多项研究表明,炎症参与了CCH引起的认知损害的发病和进展过程。在CCH状态下,脑内炎症反应的激活可导致多种病理损伤,如白质病变、血脑屏障破坏、海马神经元变性坏死等。因此,抑制炎症反应有望为CCH引起的认知损害提供新的治疗靶点。文章就炎症在CCH引起的认知损害中的作用机制进行综述。

Chronic cerebral hypoperfusion (CCH) is a common pathological change of central nervous system diseases and is closely associated with cognitive impairment. A number of studies have shown that inflammation is involved in the pathogenesis and progression of CCH-induced cognitive impairment. In the condition of CCH, the activation of inflammatory response in the brain can lead to a variety of pathological injuries, such as white matter lesions, blood-brain barrier destruction, degeneration and necrosis of hippocampal neurons, etc. Therefore, inhibition of inflammatory response is expected to provide a new therapeutic target for CCH-induced cognitive impairment. This article reviews the mechanism of inflammation in CCH-induced cognitive impairment.