细胞衰老与器官纤维化的研究进展

Progress in cellular senescence and organ fibrosis

纤维化是组织修复损伤的病理生理过程,可发生于各个器官,持续、过度的纤维化严重影响器官功能,器官纤维化是导致疾病和死亡的重要原因。老化是器官纤维化发展的重要危险因素,器官纤维化是衰老相关疾病,细胞衰老在纤维化发生、发展中起重要作用。本文就细胞衰老与器官纤维化的研究进展进行综述。

Fibrosis as a pathogenic mechanism occurs in numerous organs and diseases.Persistent and severe fibrosis affect the function of the organ.Organ fibrosis is an important cause of patient morbidity and mortality.Aging is considered as a strong risk factor for development of organ fibrosis.Organ fibrosis is age-related disease and cellular senescence plays an important role in the occurrence and development of fibrosis, which provides a new strategy for the treatment of fibrosis.This review is focused on the progress in cellular senescence and organ fibrosis.