甲硝唑棒治疗牙周病行种植牙手术患者的临床研究

Clinical study of metronidazole stilus in the treatment of periodontal disease patients undergoing dental implant surgery

目的探讨甲硝唑棒治疗牙周病行种植牙手术患者的临床疗效及对牙龈指数(gingival index,GI)、牙周袋深度(periodontal depth,PD)、牙齿松动度和龈沟出血指数(sulcus bleeding index,SBI)的影响。方法以2016年2月至2018年5月合肥市第二人民医院收治的118例行种植牙手术的牙周病患者为研究对象,并对所有患者的临床及随访资料进行回顾性分析,按照治疗方案的不同将其分为观察组和对照组,各59例。观察组在种植牙手术前给予甲硝唑棒治疗,对照组在种植牙手术前给予碘甘油药液治疗。比较2组患者治疗疗效、不良反应发生情况、治疗后6个月牙周炎的复发情况及术前、术后1周GI、PD、牙齿松动度、SBI水平。结果观察组治疗总有效率(94.92%)高于对照组(77.97%)(χ^2=7.230,P=0.007);2组患者治疗前GI、PD、牙齿松动度、SBI水平比较均无显著差异(P>0.05),治疗后2组患者GI、PD、牙齿松动度、SBI水平均较治疗前均显著下降(P<0.05),且观察组GI、PD、牙齿松动度、SBI水平均较对照组显著下降(P<0.05);2组患者不良反应总发生率比较,差异无统计学意义(χ^2=0.100,P=0.752);观察组治疗6个月后牙周炎的复发率(3.39%)低于对照组(13.56%),差异具有统计学意义(χ^2=3.933,P=0.047)。结论在牙周病行种植牙手术患者中应用甲硝唑棒治疗效果显著,可有效改善牙齿松动度、GI、PD等相关临床症状,降低牙周炎复发率。

Objective To study the clinical efficacy of metronidazole stilus in the treatment of periodontal disease patients undergoing dental implant surgery and its effects on tooth mobility,gingival index(GI),periodontal depth(PD) and sulcus bleeding index(SBI). Methods A total of 118 cases of patients with periodontal disease treated in our hospital from February 2016 to May 2018 were studied.The clinical records and follow-up data of all patients were analyzed retrospectively.According to the treatment regimens before dental implantation,the patients were divided into observation group and control group(59 cases each). The observation group was treated with metronidazole stilus,while the control group was treated with iodine glycerol.The curative effect,adverse reactions,recurrence of periodontitis at 6 months after treatment,GI,PD,tooth mobility and SBI level were compared between the two groups.Results The total effective rate in the observation group(94.92%)was higher than that in the control group(77.97%)(χ^2=7.230,P=0.007). There was no difference in the levels of GI,PD,tooth mobility and SBI between the two groups before treatment(P>0.05),but the levels of GI,PD,tooth mobility and SBI in the two groups were lower than those before treatment(P<0.05). The levels of GI,PD,tooth mobility and SBI in the observation group were significantly lower than those in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (χ^2=0.100,P=0.752). The recurrence rate of periodontitis in the observation group(3.39%)was statistically lower than that in the control group(13.56%)(χ^2=3.933,P=0.047). Conclusion Metronidazole stilus is effective in the treatment of periodontal disease patients undergoing dental implants.It can effectively improve the tooth mobility,GI,PD and other related clinical symptoms,and reduce the recurrence rate of periodontitis.