人参花蕾中的1个新皂苷5,6-二脱氢-20（S）-人参皂苷Rg3

5,6-Didehydro-20（S）-ginsenoside Rg3,a novel triterpenoid saponin from flower buds of Panax ginseng

目的研究人参Panax ginseng花蕾中的人参皂苷类化学成分。方法采用Diaion HP-20、MCI gel、硅胶及半制备高效液相等柱色谱方法进行分离、纯化,根据NMR、MS等谱学数据进行结构鉴定。结果从人参花蕾中分离得到了4个化合物,分别鉴定为6'-乙酰人参皂苷F1(1)、12α-羟基人参皂苷Rd(2)、20(S)-人参皂苷Rg3(3)及5,6-二脱氢-20(S)-人参皂苷Rg3(4)。结论化合物4为1个新的化合物,化合物1和2为新的天然产物。

Objective To study the chemical constituents of ginsenosides from the flower buds of Panax ginseng. Methods The compounds were isolated and purified by Diaion HP-20, MCI gel, silica gel, and semi-preparative HPLC. The structures were elucidated based on NMR and MS data. Results Four compounds were isolated from the extract of P. ginseng flower buds, and identified as 6′-acetyl-ginsenoside F1(1), 12α-hydroxyl-ginsneoside Rd(2), 20(S)-ginsenoside Rg3(3), and 5,6-didehydro-20(S)-ginsenoside Rg3(4). Conclusion Compound 4 is a novel ginsenoside, compounds 1 and 2 are new natural products.