柴归颗粒对抑郁症伴发症状的改善作用研究

Study on antidepressant effect of Chaigui Granules on symptoms associated with depression

目的探讨柴归颗粒(复方柴归方的制剂)对抑郁症伴发症状的改善作用,研究该药物的药效特点。方法采用慢性温和不可预知应激(CUMS)模型模拟轻、中度抑郁症,考察柴归颗粒对CUMS大鼠在Morris水迷宫实验、高架十字迷宫实验、胃肠功能测试实验中的影响。结果柴归颗粒各剂量均能显著降低Morris实验中大鼠平台探索潜伏期(P<0.05),增加进入平台次数(P<0.05);能够显著增加高架十字迷宫实验中进入开臂时间比例和进入开臂次数比例(P<0.05、0.01);柴归颗粒低、中剂量(生药4.2、8.3 g/kg)能够显著降低大鼠胃内残留率(P<0.05),柴归颗粒高、中、低剂量(生药16.6、8.3、4.2 g/kg)均能显著增加小肠推进率(P<0.05、0.01)。结论柴归颗粒能够明显改善CUMS模型引起的大鼠学习记忆能力下降、焦虑样情绪、胃肠功能障碍,表明其不仅能够明显改善抑郁症状,而且对其伴发症状具有显著的改善或缓解作用。

Objective To investigate the antidepressant effect of Chaigui Granules on the symptoms associated with depression.Methods The chronic mild unpredictable stress(CUMS)model was used to simulate mild to moderate depression.The effects of Chaigui Granules on rats in Morris water maze test,the elevated plus maze test and the gastrointestinal function test were investigated.Results In all doses of Chaigui Granules,the latency of platform exploration in Morris experiment was significantly reduced(P<0.05)and the number of times entering the platform was increased(P<0.05).The ratio of open-arms time and the frequency of open-arms entries in the elevated plus maze experiment were also increased(P<0.05,P<0.01).The gastric residual rate was significantly reduced(P<0.05)in the low and middle dose group,and the propulsion rate of intestinum tenue was increased(P<0.05,P<0.01)in all group.Conclusion The results showed that Chaigui Granules obviously improved the decreased ability of learning and memory,anxiety,gastrointestinal dysfunction caused by CUMS model in rats,indicating that it can significantly improve the depressive symptoms and alleviate its associated symptoms.