代谢组学在中药肾毒性研究中的应用进展

Application progress on metabolomics in nephrotoxicity of Chinese materia medica

中药的肾毒性问题不容忽视,需要进行有效监测与防治。目前,生化及病理指标检测是最主要的研究手段,但存在灵敏度差、有创伤等问题。近年来,代谢组学因其系统性优势在中药肾毒性研究中展现出广阔的应用前景,且已取得一系列成果。然而要实现研究成果的临床转化,仍需要进行大样本临床研究的进一步证实。对目前代谢组学应用于中药肾毒性的毒效学、生物标志物及毒理机制等方面的研究现状进行总结,以期为中药肾毒性研究提供参考。

The nephrotoxicity of Chinese materia medica(CMM)can't be ignored so that it needs effective monitor and prevention.Recently,the determination of biochemistry and pathology indexes is the most important means of research with low sensitivity and trauma.In recent years,metabolomics has shown broad prospects in CMM nephrotoxicity studies due to its systematic advantages,and also achieved remarkable success.However,large clinical sample studies are still needed to realize the clinical transformation of research results.Thus,the application of metabolomics in the toxicology,assessment biomarkers and mechanism of CMM nephrotoxicity are reviewed in this paper,in order to provide references for further research.