温肾化瘀祛痰汤治疗高泌乳素血症的临床研究

Clinical study on treatment of hyperprolactinemia with warming kidney,removing stasis and phlegm decoction

目的探究温肾化瘀祛痰汤结合周期疗法降低高泌乳素血症患者泌乳素及症状评分法的临床疗效。方法选取符合纳入标准的患者,按患者意愿分为温肾化瘀祛痰汤组、温肾化瘀祛痰汤+溴隐亭组、溴隐亭组,治疗周期为3个月经周期,于入组前、治疗后进行指标测量。结果治疗前3组泌乳素值、症状评分组间比较,差异无统计学意义(p>0.05);治疗后各组泌乳素、症状评分均降低,差异有统计学意义(p<0.05),3组间比较差异有统计学意义(p<0.05)。结论温肾化瘀祛痰汤+溴隐亭组降低泌乳素及症状评分优于温肾化瘀祛痰汤组、溴隐亭组,温肾化瘀祛痰汤结合周期疗法可降低泌乳素水平。

Objective To investigate the clinical efficacy of warming kidney, removing stasis and removing phlegm decoction (WKRSRPD) combined with periodic therapy in reducing prolactin and symptom score in patients with hyperprolactinemia. Methods 102 patients who met the inclusion criteria were selected and divided into three groups according to the patients desire: WKRSRPD group, WKRSRPD+ Bromocriptine Mesilate group, and Bromocriptine Mesilate group. The treatment cycle was 3 menstrual cycles, and the indicators were measured before and after the treatment. Results There was no significant difference in prolactin value and symptom evaluation between the three groups before treatment (p>0.05). After treatment, prolactin and symptom scores of each group were decreased, and the differences were statistically significant (p<0.05), and the differences between the three groups were statistically significant (p<0.05). Conclusion WKRSRPD + Bromocriptine Mesilate group is better than WKRSRPD and Bromocriptine Mesilate group in reducing prolactin and symptom score, and WKRSRPD combined with periodic therapy can reduce prolactin level.