Snail及E-cadherin在乳腺浸润性导管癌中的表达及其意义

Nail and e-cadherin in expression and breast infiltrating ductal carcinoma meaning

目的:研究转录因子Snail及上皮钙黏素E-cadherin在乳腺浸润性导管癌中的表达,探讨二者与乳腺浸润性导管癌各临床病理因素之间的关系,并分析二者的相关性。方法:应用免疫组织化学SP法检测55例患者乳腺浸润性导管癌组织与癌旁组织中Snail及E-cadherin的表达情况。结果:E-cadherin在实验组中的阳性表达率为58.18%,在对照组中阳性表达率为98.18%,两者差异有统计学意义(P<0.01),E-cadherin的表达与患者年龄、乳腺浸润性导管癌组织学分级、HER-2相关。Snail在实验组中的阳性表达率为87.27%,在对照组中阳性表达率为12.73%,两者比较差异有统计学意义(P<0.01)。Snail的表达与乳腺浸润性导管癌组织学分级、ER、HER-2相关。由癌旁组织到乳腺浸润性导管癌组织中,E-cadherin的阳性表达呈递减,而Snail的阳性表达呈递增,且E-cadherin和Snail的表达呈负相关(r=-0.341,P<0.01)。结论:E-cadherin及Snail是患者乳腺浸润性导管癌发生、进展以及转移的重要生物学标志,与肿瘤的发生及肿瘤的浸润转移密切相关。

Objective:To study the expression of Snail and E-cadherin in invasive ductal carcinoma of the mammary gland,to investigate the relationship between them and the clinicopathological factors of invasive ductal carcinoma of the mammary gland,and to analyze the correlation between them.Method:Expression detected by immunohistochemical SP method in 55 patients with Snail and E-cadherin in breast infiltrating ductal cancer tissues and cancer adjacent tissues.Results:The positive expression of E-cadherin in the experimental group was 58.18%,in control group the positive rate was 98.18%,the difference was statistically significant(P<0.01),the expression of E-cadherin and age,invasive ductal carcinoma of the breast histological grading,HER-2.The positive expression of Snail in the experimental group was 87.27%,in control group the positive rate was 12.73%,the difference was statistically significant(P<0.01).Snail expression is associated with breast invasive ductal carcinoma histological grading,ER,HER-2.By carcinoma tissue adjacent to breast infiltrating ductal carcinoma tissues,E-cadherin positive expression will decrease,and Snail positive expression is increasing,and negatively correlated with the expression of E cadherin and q Snail(r=0.341,P<0.01).Conclusion:E-cadherin and Snail are invasive ductal breast cancer occurrence,progression and metastasis of important biological markers,and incident cancer and tumor invasion and metastasis is related closely.