放射治疗联合免疫检查点抑制剂的不良反应

Adverse events of radiotherapy combined with immune checkpoint inhibitors

放射治疗与免疫检查点抑制剂(immune-checkpoint inhibitors,ICI)在抗肿瘤方面具有协同作用,这种作用涉及与免疫系统间的复杂效应机制,并可能改善肿瘤患者的临床结果。然而,放疗联合ICI协同调节免疫应答的同时也可能引发治疗相关不良反应。鉴于联合治疗的临床研究与实践日益增加,需要关注放疗和ICI联合研究中不良反应事件的发生风险,进而评估联合治疗的安全性。

Radiation therapy and immune checkpoint inhibitors(ICI)have a synergistic effect on anti-tumor,which involves a series of complex mechanisms of effects with the immune system,and can improve the clinical outcomes of cancer patients.However,the mechanism by which radiation therapy combined with ICI synergistically modulates the immune response may also trigger treatment-related adverse events.In view of the increasing number of clinical studies and practices of combination therapy,it is necessary to pay attention to the risk of adverse events in combination therapy of radiotherapy and ICI,so as to evaluate the safety of combination therapy.