TSH、TPOAb、TRAb、TGAb检测在甲状腺疾病临床诊断中的应用研究

Applied research of detection of TSH,TPOAb,TRAb,TGAb in the diagnosis of thyroid diseases

目的:探讨血清中促甲状腺激素(TSH)、抗甲状腺过氧化物酶抗体(TPOAb)、促甲状腺素受体抗体(TRAb)、抗甲状腺球蛋白抗体(TGAb)的浓度及阳性检出率在临床诊断甲状腺疾病中的应用价值。方法:选取2015年2月至2017年9月在我院明确诊断为甲状腺疾病的240例患者作为观察组,根据疾病类型进一步分为弥漫性毒性甲状腺肿(GD)组(140例)和桥本甲状腺炎(HT)组(100例)。同时选取160例于我院体检的健康成年人作为对照组。采用电化学发光法检测TSH和TRAb的浓度,放射免疫法检测TPOAb和TGAb的浓度,并计算TSH、TPOAb、TRAb、TGAb阳性检出率,比较观察组和对照组TSH、TPOAb、TRAb、TGAb浓度和阳性检出率的差异。结果:GD组、HT组患者血清TSH、TPOAb、TRAb、TGAb的浓度和阳性检出率均高于对照组,且差异有统计学意义(均P <0. 05)。HT组患者血清中TPOAb、TGAb浓度和阳性检出率均高于GD组,差异均有统计学意义(均P <0. 05)。GD组患者血清中TRAb的浓度和阳性检出率高于HT组,差异均有统计学意义(均P <0. 05)。结论:患者血清TSH、TPOAb、TRAb、TGAb浓度及其阳性检出率在临床诊断GD和HT中具有重要参考价值。

Objective: To investigate the value of detection of thyroid stimulating hormone( TSH),thyroid peroxidase antibody( TPOAb),thyrotrophin receptor antibody( TRAb),anti-thyroglobulin antibody( TGAb) in the diagnosis of thyroid diseases. Methods: Two hundred and forty patients with thyroid disease in our hospital from Feb. 2015 to Sep. 2017 were recruited into this study as observation group,including 140 patients with Graves disease( GD group) and 100 patients with Hashimoto thyroiditis( HT group);and 160 healthy people were recruited as control group. The electrochemical luminescence method was used to detect the concentration of the serum TSH and TRAb. The radioimmunoassay method was used to detect the concentration of the serum TPOAb and TGAb. The positive rates of TSH,TPOAb,TRAb and TGAb were calculated. The concentration and positive rates of TSH,TPOAb,TRAb,TGAb were compared between observation group and control group. Results: The concentration and positive rates of TSH,TPOAb,TRAb and TGAb in GD group and HT group were statistically higher than those of the control group( P < 0. 05). The concentration and positive rates of TPOAb,TGAb in HT group were higher than those in GD group( P < 0. 05). The concentration and positive rate of TRAb in GD group were significantly higher than those in HT group( P < 0. 05). Conclusion: The concentration and positive rate of TSH,TPOAb,TRAb,TGAb are extremely important in the diagnosis of Graves diseases and Hashimoto thyroiditis.