β1肾上腺素受体失敏在脓毒症心肌功能障碍中的研究进展

Research advances of β1-adrenergic receptor desensitization in sepsis-induced myocardial dysfunction

脓毒症诱导的心肌功能障碍(SIMD)是造成脓毒症预后不良的重要原因之一.β肾上腺素受体(β-AR)信号通路系统的异常可引起心功能障碍,其中β-AR受体失敏是心功能障碍的主要原因之一,其机制包括受体解偶联、内吞和基因表达水平下调引起的受体数量、功能的降低.本文主要讨论β1-AR失敏与SIMD的关系,试图为治疗SIMD提供一定的理论依据,为后续的深入研究奠定基础.

Sepsis-induced myocardial dysfunction (SIMD) is an important cause of poor prognosis of sepsis. Abnormalities in the β-adrenergic receptor (β-AR) signaling pathway such as β-AR receptor desensitization may cause cardiac dysfunction. The mechanisms of β-AR receptor desensitization include receptor resolution, coupling, receptor endocytosis and down-regulation of gene expression, causing a decrease in the number and function of β-AR receptors. This article mainly discusses the relationship between β1-AR desensitization and SIMD, tries to provide a theoretical basis for the treatment of SIMD, and lays a foundation for further research.