分子伴侣GRP78/BiP在癌症治疗靶点中的研究进展

Advances in Molecular Chaperone GRP78/BiP in Cancer Therapeutic Targets

GRP78在化学抗性发展中的作用刚刚出现。大量研究显示GRP78基因组在几种常规治疗难以治愈的癌症中过且广泛表达。因此,GRP78不仅可以成为预测癌症化学治疗反应良好性生物标志物,而且也是选择性化疗的治疗靶标。本文主要讨论了GRP78作为生物标志物和癌症治疗靶点的相关研究进展。

The role of GRP78 in development of chemoresistance is just emerging.The increasing availability of genome wide and array data shows that GRP78 is often overexpressed in several types of cancers refractory to conventional therapy.GRP78 therefore could not only be a good biomarker to predict response to therapy but also an appealing target for a more selective chemotherapy.In this communication we review the possible role of GRP78 as a biomarker and as a target in cancer therapy.