氟比洛芬酯用于腹腔镜下阑尾切除术后疼痛临床评价

Clinical Evaluation on Flurbiprofen Axetil Injection in the Treatment of Pain After Laparoscopic Appendectomy

目的探讨氟比洛芬酯用于腹腔镜下阑尾切除术后疼痛的效果及对患者血清炎性因子水平的影响。方法选取医院2016年6月至2018年6月收治拟行腹腔镜下阑尾切术患者130例,按随机分配原则分为观察组和对照组,各65例。对照组术后立即给予曲马多肌肉注射,观察组患者术后给予氟比洛芬酯注射液静脉注射,均每日1次。两组均连续治疗5d。结果观察组患者给药后1,2,4,12,24h的静息状态视觉模拟评分量表(VAS)评分、活动状态VAS评分均显著低于对照组(P<0.05);观察组患者给药后1,2,4,12,24h的舒适度评分量表(BCS)评分均显著高于对照组(P<0.05);给药后24h时,观察组C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素10(IL-10)水平均显著低于对照组(P<0.05);观察组不良反应发生率为7.69%(5/65),与对照组的12.31%(8/65)相当(P>0.05)。结论氟比洛芬酯用于腹腔镜下阑尾切除术后镇痛的效果显著,可降低患者的炎性因子水平,提高患者的舒适度,用药安全性好,可为术后镇痛提供了新的选择方案。

Objective To investigate the clinical efficacy of flurbiprofen axetil in the treatment of pain after laparoscopic appendectomy and its effect on serum inflammatory factors. Methods Totally 130 patients underwent laparoscopic appendectomy in our hospital from June 2016 to June 2018 were selected and randomly divided into the observation group and the control group,65 cases in each group. Tramadol was injected immediately after operation in the control group and Flurbiprofen Axetil Injection was injected intravenously in the observation group. Both groups were treated once a day for 5 d. Results The Visual Analogue Scale( VAS) scores of resting-state and active-state in the observation group were significantly lower than those in the control group at 1,2,4,12,24 h after administration( P < 0. 05). The Bruggrmann Comfort Scale( BCS) scores of the observation group were significantly higher than those of the control group at 1,2,4,12,24 h after administration( P < 0. 05). The levels of C-reactive protein( CRP),tumor necrosis factor-α( TNF-α) and interleukin-10( IL-10) in the observation group were significantly lower than those in the control group at 24 h after administration( P < 0. 05). The incidence of adverse reactions in the observation group was 7. 69%( 5/65),which was similar to12. 31%( 8/65) in the control group( P > 0. 05). Conclusion Flurbiprofen axetil has significant analgesic effect and safety in the treatment of pain after laparoscopic appendectomy,which can reduce the levels of inflammatory factors,improve the patients’ comfort and provide a new choice for postoperative analgesia.