红蓝光联合口服克拉霉素运用于治疗痤疮的疗效及不良反应分析

Efficacy and side effects of red and blue light combined with oral clarithromycin in the treatment of acne

目的探讨红蓝光联合克拉霉素运用于治疗痤疮的疗效和不良反应。方法选取2016年1月-2018年3月收治的中重度痤疮患者110例,按数字随机表分为对照组和观察组,每组55例。对照组采用口服克拉霉素和雷尼替丁治疗,观察组采用红蓝光联合克拉霉素、雷尼替丁治疗,分析2组治疗有效率、治疗前后痤疮综合分级系统(GAGS)评分变化和不良反应发生率情况。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);2组治疗1个月后粉刺、脓疱、丘疹、结节和GAGS总评分均低于治疗前,且观察组治疗1个月后粉刺、脓疱、丘疹、结节和GAGS总评分均低于对照组,差异有统计学意义(P<0.05);观察组总不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论红蓝光联合克拉霉素运用于治疗中重度痤疮疗效确切,可显著提高治疗有效率,减轻临床症状,且不良反应少,安全可靠,值得推广。

Objective To investigate the efficacy and side effects of red and blue light combined with clarithromycin in the treatment of acne. Methods A total of 110 patients with moderate to severe acne treated between January 2016 and March 2018 were selected and divided into two groups according to the random number table, 55 cases in each group. The control group was treated with oral clarithromycin and ranitidine while the treatment group was treated with red and blue light combined with clarithromycin and ranitidine. The curative effect of the two groups was observed, while the GAGS score and incidence of adverse reactions were analyzed before and after treatment. Results The effective rate of the treatment group was higher than that of the control group, and the difference was statistically significant (P<0.05). The overall score of acne, pustules, papules, nodules and GAGs was lower in the two groups after one month of treatment, and the overall score of acne, pustules, nodules and GAGs was lower in the observation group than in the control group after one month of treatment, and the difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Red and blue light combined with clarithromycin is effective in the treatment of moderate and severe acne, which can significantly improve the efficiency of treatment, reduce clinical symptoms and adverse reactions, so it is safe, reliable and should be made more accessible.