肤康舒方治疗老年性皮肤瘙痒症疗效观察

Observation on the Therapeutic Effect of Fukangshu Prescriptionon Senile Pruritus

目的探讨肤康舒方治疗老年性皮肤瘙痒症的临床疗效并评估其药物安全性。方法将本院门诊就诊的62例老年性皮肤瘙痒症患者按随机数字表的方式分为对照组与观察组各31例,其中对照组予每日1次口服西替利嗪,观察组予每日1次沐浴时外用肤康舒方,4周后对比2组的临床疗效,症状、体征积分,皮肤病生活质量指数评分(DLQI),药物不良反应事件。结果治疗后,组间对比,观察组总有效率显著高于对照组,差异具有统计学意义(P<0.05)。治疗后,组内对比,2组瘙痒程度、瘙痒面积、继发皮损评分均较治疗前降低,差异具有统计学意义(P<0.05);组间对比,观察组瘙痒程度、瘙痒面积、继发皮损评分降低明显,差异具有统计学意义(P<0.05)。治疗后,组内对比,2组DLQI评分均较治疗前降低;组间对比,观察组DLQI评分降低明显,差异具有统计学意义(P<0.05)。治疗后,观察组药物不良反应事件发生率为0.00%,明显低于对照组(9.68%),差异具有统计学意义(P<0.05)。结论肤康舒方治疗老年性皮肤瘙痒症具有明显的疗效,可明显缓解瘙痒,提高皮肤病患者生活质量,且安全可靠,适合在岭南地区进一步推广应用。

Objective: To study the clinical effect of Fukangshu prescription in the treatment of senile pruritus and to evaluate its drug safety. Methods: 62 patients with senile pruritus from the outpatient department of our hospital were randomly divided into a control group and an observation group, 31 cases per group. The control group was given oral cetirizine once a day and the observation group was given external Fukangshu prescription in shower once a day. The clinical effects, symptoms and signs scores, skin disease of life quality index score(DLQI), and adverse drug reaction events of the two groups were compared after 4 weeks. Results: After treatment, the total effective rate of the observation group was significantly higher than that of the control group, and the difference was statistically significant(P<0.05). After treatment, the comparison between the intra-groups showed the degree of pruritus, pruritus area, and secondary skin lesion scores were lower than those of the pre-treatment, and the difference was statistically significant(P<0.05). After treatment, the comparison between the inter-groups showed the degree of pruritus, pruritus area, secondary skin lesion scores decreased significantly, and the difference was statistically significant(P<0.05). After treatment, in the intragroup comparison, DLQI scores of the two groups were lower than that of the pre-treatment, and in the intergroup comparison, DLQI score of the observation group decreased significantly, and the difference was statistically significant(P<0.05). After treatment, the incidence of adverse drug reactions in the observation group was 0.00%, significantly lower than that in the control group(9.68%), and the difference was statistically significant(P<0.05). Conclusion: Fukangshu prescription has obvious therapeutic effect on senile pruritus and can relieve itching and improve the quality of life of patients with skin diseases. It is safe and reliable and suitable for further application in Lingnan area.