凝血功能、血气分析及血清氨基末端脑钠肽前体水平在慢性阻塞性肺疾病中的临床监测意义

Clinical significance of coagulation function,blood gas analysis and serum serum amino terminal pro-brain natriuretic peptide level in patients with chronic obstructive pulmonary disease

目的探讨凝血功能、血气分析及血清氨基末端脑钠肽前体(NT-proBNP)水平在慢性阻塞性肺疾病中的临床意义.方法选取120例慢性阻塞性肺疾病患者,按病程不同分为急性组(60例)、稳定组(60例),另选同期健康体检者60例设为对照组,检测3组受检者的凝血功能、血气分析及血清NT-proBNP水平.结果急性组、稳定组的活化部分凝血活酶时间(APTT)、纤维蛋白原(FBG)、D-二聚体(D-D)水平显著高于对照组,而急性组显著高于稳定组(P<0.05);急性组、稳定组患者的氧分压[p(O2)]水平显著低于对照组,二氧化碳分压[p(CO2)]水平显著高于对照组,而急性组p(O2)水平显著低于稳定组、p(CO2)水平显著高于稳定组(P<0.05);急性组、稳定组的血清NT-proBNP水平均显著高于对照组,而急性组的血清NT-proBNP水平显著高于稳定组(P<0.05);NT-proBNP水平与凝血功能各指标呈正相关性,与p(CO2)呈正相关性,与p(O2)呈负相关性(P<0.01).结论凝血功能、血气分析及血清NT-proBNP水平可有效监测慢性阻塞性肺疾病患者病情及评估预后,临床应用价值高.

Objective To investigate the clinical significance of coagulation function, blood gas analysis and serum amino terminal pro-brain natriuretic peptide (NT-proBNP) levels in patients with chronic obstructive pulmonary disease. Methods A total of 120 patients with chronic obstructive pulmonary disease admitted to our hospital were divided into acute group and stable group, with 60 patients in per group. At the same time, another 60 healthy controls in the same period were as the control group. Coagulation function, blood gas analysis and serum NT-proBNP levels were measured in the three groups. Results The thrombin time (APTT), fibrinogen (FBG)and D-dimmer (DD)in the acute group and the stable group were higher than those in the control group, and the acute group was higher than the stable group( P <0.05). The oxygen partial pressure[ p (O 2)] level, partial pressure of carbon dioxide[ p (CO 2)] in the acute group and the stable group was higher than that in the control group. The level of p (O 2) in the acute group was lower, and the level of p (CO 2) was higher than that in the stable group ( P <0.05). The levels of serum NT-proBNP in the acute group and stable group were higher when compared with the control group, the level of serum NT-proBNP in the acute group was higher than that in the stable group ( P <0.05). NT-proBNP was positively correlated with coagulation function and p (CO 2), and was negatively correlated with p (O 2)( P < 0.05). Conclusion Coagulation function, blood gas analysis and serum NT-proBNP level can effectively monitor the condition and monitor prognosis of chronic obstructive pulmonary disease, and it has higher clinical value.