盐酸乙哌立松治疗痉挛性脑瘫患儿的临床疗效观察

Clinical effect of eperisone hydrochloride in the treatment of children with spastic cerebral palsy

目的 探讨盐酸乙哌立松治疗痉挛性脑瘫患儿的临床效果。方法 选取84例痉挛性脑瘫患儿作为研究对象,按照随机数字表法分为Ⅰ组(盐酸乙哌立松治疗组)、Ⅱ组(盐酸苯海索治疗组)、Ⅲ组(氯硝西泮治疗组),对比各组治疗效果、肌张力缓解情况以及药物不良反应发生率。结果 Ⅰ组治疗效果显著优于Ⅱ组和Ⅲ组( P <0.05);治疗前, 3组肌张力水平无显著差异( P >0.05),治疗后, 3组患儿肌张力均有所好转,但Ⅰ组和Ⅲ组的肌张力评分显著低于Ⅱ组( P <0.05);治疗期间,Ⅲ组不良反应发生率最高,Ⅰ组不良反应发生率最低,组间差异显著( P <0.05)。结论 采用盐酸乙哌立松治疗小儿痉挛性脑性瘫痪效果佳,不仅能有效改善患儿肌张力障碍,而且具有较高的安全性。

Objective To explore the clinical effect of eperisone hydrochloride in the treatment of children with spastic cerebral palsy. Methods A total of 84 children with spastic cerebral palsy in our hospital were selected. According to the random number table method, these patients were assigned to group Ⅰ(eperisone hydrochloride treatment group), group Ⅱ(benzhexol hydrochloride treatment group) and group Ⅲ(clonazepam treatment group). The therapeutic effect, relief conditions of muscular tension and incidence of adverse reactions were compared. Results The therapeutic efficacy in group Ⅰwas better than group Ⅱand group Ⅲ( P <0.05). Before treatment, the muscular tension in three groups showed no statistically significant differences ( P >0.05);after treatment, it was greatly improved in three groups, and the muscular tension scores in group Ⅰand group Ⅲwere lower than group Ⅱ( P <0.05). The incidence of adverse reactions was the highest in group Ⅲ, and lowest in group Ⅰ( P <0.05). Conclusion Eperisone hydrochloride can remarkably relieve the dystonia and increase the clinical safety.