单唾液酸四己糖神经节苷脂联合亚低温治疗新生儿窒息并发缺氧缺血性脑病的预后评价

Evaluation on prognosis of neonatal asphyxia patients complicated with hypoxic ischemic encephalopathy treated by monosialotetrahexosylganglioside combined with mild hypothermia

目的 探讨单唾液酸四己糖神经节苷脂(GM1)联合亚低温治疗新生儿窒息并发缺氧缺血性脑病(HIE)的预后。方法 选取本院收治的80例窒息并发HIE患儿,按随机数字表法分为对照组( n =40,亚低温)及观察组( n =40, CM1联合亚低温),比较2组患儿治疗效果。结果 观察组治疗后新生儿神经行为测定(NBNA)评分高于对照组,氧化应激反应改善程度优于对照组,差异有统计学意义( P <0.05);观察组吸吮能力、意识、原始反射及肌张力恢复时间短于对照组,后遗症总发生率低于对照组,差异有统计学意义( P <0.05)。结论 GM1联合亚低温治疗新生儿窒息并发HIE可改善患儿神经功能。

Objective To investigate the prognosis of neonatal asphyxia patients complicated with hypoxic ischemic encephalopathy (HIE) treated by monosialotetrahexosylganglioside (GM1) combined with mild hypothermia therapy. Methods A total of 80 neonates with neonatal asphyxia complicated with HIE admitted to our hospital were divided into control group ( n =40, mild hypothermia) and observation group ( n =40, CM1 combined with mild hypothermia) according to the random number table method. The therapeutic effects of the two groups were compared. Results After treatment, the Neonatal Behavioral Neurological Assessment (NBNA) scores in the observation group was higher than that in the control group, and the improvement of oxidative stress response was better than that in the control group ( P <0.05). The recovery time of sucking ability, consciousness, original reflex and muscle tension in the observation group were shorter than that in the control group, and the total incidence of sequelae was lower than that in the control group ( P <0.05). Conclusion Monosialotetrahexosylganglioside combined with mild hypothermia therapy in the treatment of neonatal asphyxia complicated with HIE can improve the neurological function of infants.