中药灌肠联合温针灸治疗慢性期远端结肠型溃疡性结肠炎的疗效评价

Efficiency evaluation of enema with traditional Chinese medicine combined with needle-warming moxibustion in the treatment of chronic distal ulcerative colitis

目的 探讨中药灌肠联合温针灸治疗远端结肠型溃疡性结肠炎的疗效。方法 将90例远端结肠型溃疡性结肠炎患者分为3组。在常规西药基础上,中药灌肠组予以中药灌肠,温针灸组予以温针灸治疗,联合治疗组则予以中药灌肠联合温针灸治疗。比较3组患者的临床疗效、生化指标及炎症因子水平、中医症状评分、结肠镜评分、结肠组织病理评分、黏膜愈合及复发情况、不良反应。结果 联合治疗组临床治疗总有效率显著高于中药灌肠组及温针灸组( P <0.05);联合治疗组治疗后白细胞计数(WBC)、血小板(PLT)、肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)水平均显著低于中药灌肠组及温针灸组( P <0.05);联合治疗组治疗后中医症状评分、结肠镜评分、结肠组织病理评分均显著低于中药灌肠组及温针灸组( P < 0.05);联合治疗组黏膜愈合率、复发率均显著优于中药灌肠组及温针灸组( P <0.05);3组不良反应发生率差异无统计学意义( P >0.05)。结论 中药灌肠联合温针灸治疗远端结肠型慢性溃疡性结肠炎的疗效显著,可显著改善中医症状,降低生化指标与炎症因子水平。

Objective To explore the efficacy of enema with traditional Chinese medicine combined with needle-warming moxibustion in the treatment of chronic distal ulcerative colitis. Methods A total of 90 patients with distal ulcerative colitis were divided into three groups. On the basis of routine western medicine, Chinese medicine enema group was treated with Chinese medicine for enema, needle-warming moxibustion group was treated with needle-warming moxibustion, and combined treatment group was treated with Chinese medicine for enema and needle-warming moxibustion. The clinical efficacy, biochemical indicators and inflammatory factors, TCM symptom score, colonoscopy score, colon histopathological score, mucosal healing and recurrence, and adverse reactions of the two groups were compared. Results The total effective rate of combined treatment group was significantly higher than that of Chinese medicine enema group and needle-warming moxibustion group ( P <0.05). The levels of white blood cell count (WBC), platelet (PLT), tumor necrosis factor-α(TNF-α) and interleukin-8 (IL-8) after treatment in combined treatment group were significantly lower than those in Chinese medicine enema group and needle-warming moxibustion group ( P < 0.05). After treatment, TCM symptom score, colonoscopy score and colon histopathological score in combined treatment group were significantly lower than those of Chinese medicine enema group and needle-warming moxibustion group ( P <0.05), and mucosal healing rate and recurrence rate were significantly better than those of Chinese medicine enema group and needle-warming moxibustion group ( P <0.05). There were no significant differences in the incidence rate of adverse reactions among the three groups ( P >0.05). Conclusion Traditional Chinese medicine for enema combined with needle-warming moxibustion is effective in the treatment of chronic distal ulcerative colitis, which can significantly improve the TCM symptoms and reduce the levels of biochemical indicators and inflammatory factors.