阿司匹林联合瑞舒伐他汀治疗老年短暂性脑缺血患者并发脑梗死的效果观察

Efficacy observation of aspirin combined with rosuvastatin in the treatment of elderly patients with transient ischemic attack complicated with cerebral infarction

目的研究阿司匹林联合瑞舒伐他汀治疗老年短暂性脑缺血患者并发脑梗死的效果。方法按照入院时间将140例老年短暂性脑缺血引发初次脑梗死患者分为对照组与观察组。对照组口服阿司匹林,观察组患者口服阿司匹林、瑞舒伐他汀。随访12个月,记录2组患者的不良反应、短暂性脑缺血及缺血性脑梗死的再发率。用药前及用药第6、12个月时,测定患者血脂水平[甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、C-反应蛋白(CRP)]。结果观察组短暂性脑缺血、缺血性脑梗死的再发率显著低于对照组(P <0. 05);观察组用药第6、12个月的TC、TG、LDL-C、CRP水平显著降低,HDL-C水平显著升高(P <0. 05)。2组患者均未出现严重不良反应。结论瑞舒伐他汀与阿司匹林联合治疗能显著改善短暂性脑缺血患者血脂的异常情况,降低CRP水平及短暂性脑缺血发作、缺血性脑梗死的再发率。

Objective To explore the efficacy of aspirin combined with rosuvastatin in the treatment of elderly patients with transient ischemic attack complicated with cerebral infarction. Methods According to the time of hospital admission, a total of 140 patients with transient ischemic attack and initial cerebral infarction were divided into control group and observation group. The control group was treated with aspirin orally, while the observation group was treated with aspirin and rosuvastatin orally. After 12 months of follow-up, adverse reactions, recurrence rate of transient cerebral ischemia and recurrence rate of ischemic cerebral infarction were recorded in both groups. At the time points of before medication, 6 months and 12 months after medication, levels of blood lipid indexes such as triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and C-reactive protein (CRP) were detected. Results The recurrence rates of transient cerebral ischemia and ischemic cerebral infarction in the observation group were significantly lower than those in the control group ( P <0.05). After 6 and 12 months of treatment, the levels of TC, TG, LDL-C and CRP in the observation group significantly decreased ( P < 0.05), while HDL-C level significantly increased ( P <0.05). There were no severe adverse reactions in both groups. Conclusion For patients with transient ischemic attack, combination of rosuvastatin and aspirin can significantly improve dyslipidemia, reduce CRP level and recurrence rates of transient ischemic attack and ischemic cerebral infarction.