阿奇霉素序贯疗法联合沙丁胺醇对肺炎支原体肺炎患儿炎症反应的影响

Effect of azithromycin sequential therapy combined with calbutamol on inflammatory response in children with mycoplasma pneumoniae pneumonia

目的探讨阿奇霉素序贯疗法联合沙丁胺醇对肺炎支原体肺炎患儿炎症反应的影响。方法选取2016年9月~2018年3月我院收治的94例肺炎支原体肺炎患儿作为研究对象,随机分为实验组(n=47)与对照组(n=47)。对照组单纯采用阿奇霉素序贯疗法进行治疗,实验组给予阿奇霉素序贯疗法联合沙丁胺醇治疗,比较两组治疗效果、临床症状消失时间、炎症反应相关指标[C反应蛋白(CRP)、降钙素原(PCT)]以及不良反应发生情况。结果与对照组相比,实验组治疗总有效率更高、临床症状消失时间更短,差异有统计学意义(P<0.05);治疗后,实验组CRP以及PCT水平均明显低于治疗前与对照组,差异有统计学意义(P<0.05);两组不良反应发生率相比,差异无统计学意义(P>0.05)。结论阿奇霉素序贯疗法联合沙丁胺醇治疗小儿肺炎支原体肺炎疗效确切,安全性高,可快速缓解患儿的临床症状,减轻机体的炎症反应。

Objective To discuss the effect of azithromycin sequential therapy combined with salbutamol on inflammatory response in children with mycoplasma pneumoniae pneumonia (MPP). Methods A total of 94 cases with MPP admitted in the hospital from September 2016 to March 2018 were selected as subjects,and were randomly divided into the experimental group (n=47) and the control group (n=47).The control group was given azithromycin sequential therapy,while the experimental group was treated with azithromycin sequential therapy and salbutamol. The curative effects,disappearance time of clinical symptoms,inflammatory response index [C-reactive protein (CRP),procalcitonin (PCT)], and adverse reactions were compared between the two groups. Results Compared with the control group,the total curative effective rate of experimental group was higher,and the disappearance time of clinical symptoms in experimental group was shorter(P < 0.05);After treatment,the levels of CRP and PCT in experimental group were lower than those before treatment and in the control group (P < 0.05);There was no statistical difference in the rates of adverse reactions between the two groups (P > 0.05). Conclusion Azithromycin sequential combined with salbutamol in treatment of children with MPP is effective and safe,and it can quickly relieve clinical symptoms and reduce inflammatory response.