宫颈癌术后调强放疗中限定与非限定骨盆骨髓剂量的效果对比

Comparison of the effects of limited and unlimited pelvic bone marrow doses in postoperative intensity-modulated radiation therapy for cervical cancer

目的对比观察宫颈癌术后调强放疗中限定与非限定骨盆骨髓剂量的效果。方法随机将2012年6月~2015年6月本院收治的78例宫颈癌术后调强放疗患者分为对照组、实验组,对照组采用非限定骨盆骨髓剂量,实验组采用限定骨盆骨髓剂量,比较两组疗效。结果实验组骨盆剂量体积、血液毒性反应明显低于对照组,差异有统计学意义(P<0.05);实验组膀胱、直肠、小肠的剂量体积,靶区剂量适形指数(CI)、均匀指数(HI)、泌尿系统及消化道毒性反应与对照组比较,差异无统计学意义(P>0.05)。结论对宫颈癌术后调强放疗患者给予限定骨盆骨髓剂量在满足靶区放疗剂量需求的同时降低了骨盆剂量体积、血液毒性反应发生率,提高了放疗安全性。

Objective To compare and observe the effects of limited and unlimited pelvic bone marrow doses in postoperative intensity-modulated radiation therapy for cervical cancer. Methods 78 patients with cervical cancer who underwent postoperative intensity-modulated radiation therapy in our hospital from June 2012 to June 2015 were randomly divided into the control group and the experimental group.The control group was given unlimited pelvic bone marrow doses while the experimental group was given limited pelvic bone marrow doses.The curative effects of the two groups were compared. Results The pelvic dose volume and blood toxicity of the experimental group were significantly lower than those of the control group,and the difference was statistically significant(P < 0.05).There was no statistically significant difference in the dose volume of bladder,rectum and small intestine,target dose conformal index(CI),homogeneity indexes(HI)and toxicity of urinary system and digestive system between the experimental group and the control group(P > 0.05). Conclusion In patients with cervical cancer after intensity-modulated radiation therapy,the limited pelvic bone marrow dose reduces the pelvic dose volume and the incidence of blood toxicity and improves the safety of radiotherapy while meeting the needs of radiotherapy dose of the target area.