妇科门诊患者解脲脲原体、沙眼衣原体、淋球菌和人乳头瘤病毒感染特点及相关性分析

Characteristics and correlation analysis of UU,CT,NG and HPV infection in gynecological outpatients

目的 了解妇科门诊妇女性传播疾病病原体感染情况,并探讨不同病原体感染的相关性。方法 选取2016年2月至2017年11月来北京天坛医院就诊的2 064例妇科门诊妇女宫颈上皮细胞标本,采用基因扩增及导流杂交技术进行解脲脲原体(UU)、沙眼衣原体(CT)、淋球菌(NG)和人乳头瘤病毒(HPV)检测。结果 2 064例样本中检出UU/CT/NG感染1 335例(UU/CT/NG一种阳性即为阳性),感染率为64.68%,其中以UU感染为主(1 331例)。感染类型以单一感染为主。在年龄分布上有2个感染高峰,分别为≤30岁和41~50岁2个年龄段,感染率分别为68.20%和70.25%。其中有1 090例患者同时进行了HPV分型检测,检出HPV阳性样本205例,以高危型别感染和单一感染为主。1 090例样本中,UU/CT/NG阳性组其HPV感染率为23.40%,明显高于UU/CT/NG阴性组(10.54%),差异有统计学意义( P <0.01),相关系数 r =0.157。结论 妇科门诊妇女性传播疾病病原体以UU为主,UU/CT/NG感染人群易合并HPV感染,二者具有协同作用。

Objective To investigate the prevalence of sexually transmitted diseases (STDs) among women in gynecological clinics,and to explore the correlation between different pathogens. Methods From February 2016 to November 2017,2 064 cervical epithelial cell specimens from gynecologic outpatient women in Beijing Tiantan Hospital were selected for detection of ureaplasma urealyticum (UU),chlamydia trachomatis (CT),neisseria gonorrhoeae (NG) and human papillomavirus (HPV) by gene amplification and conduction hybridization. Results UU/CT/NG infection was detected in 1 335 of 2 064 samples (positive for one type of UU/CT/NG),the infection rate was 64.68%.UU infection was predominant (1 331 cases).The main type of infection was single infection.There were two peaks of infection in the age distribution,which were ≤ 30 years old and 41-50 years old respectively.The infection rates were 68.20% and 70.25% respectively.Among them,1 090 patients were tested for HPV typing at the same time.205 HPV positive samples were detected,mainly high-risk type infection and single infection.The HPV infection rate in UU/CT/NG positive group was 23.40 %,which was significantly higher than that in UU/CT/NG negative group (10.54%).The difference was statistically significant ( P <0.01),and the correlation coefficient r =0.157. Conclusion UU is the main pathogen of sexually transmitted diseases in women in gynecological clinics.People infected with UU/CT/NG are liable to be infected with HPV.Both of them have synergistic effect.The pathogens of sexually transmitted diseases in gynecological outpatient women are mainly UU,and people infected with UU/CT/NG are prone to HPV infection,and the two have a synergistic effect.