SAA、WBC及免疫因子在小儿支气管肺炎患者中的表达及临床价值研究

Expression and clinical value of SAA,WBC and immune factors in children with bronchopneumonia

目的 探讨血清淀粉样蛋白A(SAA)、白细胞计数(WBC)及免疫因子在小儿支气管肺炎患者中的表达及临床价值。方法 选取江苏省海安市人民医院2016年8月至2017年8月治疗的小儿支气管肺炎患者72例为研究组,选择同期入院体检健康儿童72例为对照组,观察并比较2组研究对象SAA、WBC和C反应蛋白(CRP)、免疫球蛋白A(IgA)、免疫球蛋白AM(IgM)、免疫球蛋白G(IgG)及红细胞免疫指标水平。结果 研究组患儿的SAA、WBC和CRP水平明显高于对照组( P <0.05);对照组患儿的IgA、IgM及IgG水平显著高于研究组( P <0.05)。研究组患儿免疫黏附抑制因子(FEIR)、红细胞免疫复合物花环(RBC-ICR)水平明显高于对照组( P <0.05),而红细胞C3b受体花环(RBC-C3bR)和免疫黏附促进因子(FEER)水平明显低于对照组( P < 0.05 )。结论 小儿支气管肺炎患者与体检健康者在WBC、SAA及免疫因子方面存在较大差异,对于疾病的诊断具有重要作用。

Objective To investigate the expression and clinical value of serum amyloid protein A (SAA),white blood cell count (WBC) and immune factors in children with bronchopneumonia. Methods Totally 72 children with bronchial pneumonia treated in Haian People′s Hospital of Jiangsu Province from August 2016 to August 2017 were selected as the study group,72 healthy people admitted to the hospital during the same period were selected as the control group,and the levels of SAA,WBC,CRP,IgA,IgM,IgG and erythrocyte immune indexes were observed and compared between the two groups. Results The indexes of SAA,WBC and CRP in the study group were significantly higher than those in the control group ( P <0.05),and the levels of IgA,IgM and IgG in the control group were significantly higher than those in the study group ( P < 0.05 ).The levels of FEIR and RBC-ICR in the study group were significantly higher than those in the control group ( P <0.05),while the levels of RBC-C3bR and FEER in the study group were significantly lower than those in the control group ( P <0.05). Conclusion The results of this study show that there are great differences in WBC,SAA and immune factors between children with bronchopneumonia and normal children.It plays an important role in the diagnosis of diseases and is worthy of further clinical application and promotion.