循环肿瘤细胞检测在肺癌中的应用

The detection of circulating tumor cells and its application in lung cancer

肺癌是目前全世界范围内发病率和病死率最高的恶性肿瘤,早期诊治是改善其预后的关键,随着循环肿瘤细胞(CTCs)检测技术的改进与发展,检测的灵敏度与特异度逐步提高,肺癌患者将在早期得到确诊,对肺癌的诊断、治疗及预后评估都具有重要意义。本文重点综述了近年来CTCs检测诊断技术的进展及其在肺癌诊断中的应用,并对其检测技术面临的挑战进行了探讨。

: Lung cancer has the highest morbidity and mortality in the world.Early diagnosis and treatment is the key to improve its prognosis.With the improvement and development of circulating tumor cells (CTCs) detection technology,the sensitivity and specificity of detection are gradually improved.Lung cancer patients will be diagnosed at an early stage,which is of great significance for the diagnosis,treatment and prognosis evaluation of lung cancer.In this paper,the progress of CTCs detection and diagnosis technology in recent years and its application in lung cancer diagnosis are reviewed,and the challenges faced by CTCs detection technology are discussed.