超声造影联合肿瘤标志物对卵巢良恶性肿瘤的诊断价值

Diagnostic value of contrast-enhanced ultrasound combined with tumor markers in benign and malignant ovarian tumors

目的探讨超声造影联合肿瘤标志物对卵巢良恶性肿瘤的诊断价值。方法回顾性分析2016年5月至2017年5月本院收治的、有完整临床资料且行超声造影、肿瘤标志物糖类抗原(CA) 125、CA199检测的卵巢肿瘤患者100例的临床资料,分析良恶性卵巢肿瘤超声造影的参数特点,测定肿瘤标志物水平,并分析超声造影与肿瘤标志物单独或联合对卵巢良恶性肿瘤的检出率。结果与良性肿瘤相比,卵巢恶性肿瘤具有不均匀增强、造影强化始增及达峰时间较早、速率增强较高的特点(P<0.05);与良性卵巢肿瘤患者相比,卵巢恶性肿瘤患者血清CA125、CA199水平更高,差异有统计学意义(P<0.05);对超声造影、肿瘤标志物、超声造影联合肿瘤标志物检出率进行对比,超声造影联合肿瘤标志物检出率高于超声、肿瘤标志物单项检测,且与病理标准较为相符。结论应用联合超声造影及肿瘤标志物对卵巢良恶性肿瘤诊断具有较高检出率,能够显著提升临床检测准确率,为治疗提供有力依据。

Objective To explore the diagnostic value of contrast-enhanced ultrasound combined with tumor markers in benign and malignant ovarian tumors.Methods The clinical data of 100 patients with ovarian tumors treated in our hospital from May 2016 to May 2017 were analyzed retrospectively.The parameters of contrast-enhanced ultrasonography (CEUS) for benign and malignant ovarian tumors were analyzed.The levels of tumor markers were measured and the ultrasound imaging was analyzed.Analysis of the detection rate of benign and malignant ovarian tumors by contrast-enhanced ultrasound alone or in combination with tumor markers.Results Compared with benign ovarian tumors,ovarian malignant tumors have the characteristics of uneven enhancement,early onset and peak time of contrast enhancement,and higher rate of enhancement (P<0.05);compared with benign ovarian tumors,serum CA125 and CA199 levels in patients with ovarian malignant tumors were higher,with significant difference (P<0.05).The detection rates of contrast-enhanced ultrasound combined with tumor markers were higher than those of ultrasound or tumor markers alone,and were in accordance with pathological criteria.Conclusions The application of combined contrast-enhanced ultrasound and tumor markers in the diagnosis of ovarian benign and malignant tumors has a high detection rate,can significantly improve the accuracy of clinical detection,and provide a strong basis for treatment.