鼠神经生长因子联合早期康复干预治疗巨细胞病毒感染听力损伤的疗效

Curative effect of rat nerve growth factor combined with early rehabilitation intervention in the treatment of hearing injury caused by cytomegalovirus infection

目的探讨鼠神经生长因子联合早期康复干预治疗巨细胞病毒(CMV)感染听力损伤的疗效。方法将2012年1月至2018年2月本院确诊的106例巨细胞病毒感染听力损伤患儿随机分为观察组和对照组,各53例。对照组予更昔洛韦及综合康复治疗,观察组在对照组治疗基础予鼠神经生长因子治疗。两组患儿在治疗前后均行多频稳态诱发电位检查、巨细胞病毒抗体及DNA荧光定量,母亲行巨细胞病毒抗体检查。比较两组疗效的总有效率和观察组不同程度听力损伤的有效率,比较观察组先天性和后天获得性CMV感染引起听力损伤治疗后的疗效差异。结果观察组治疗总有效率为80.7%,高于对照组65.9%(P<0.05);观察组轻、中度听力损伤的治疗总有效率高于重度听力损伤(P<0.05);观察组后天获得性CMV感染引起听力损伤的治疗总有效率高于先天性CMV感染引起听力损伤(P<0.05)。结论鼠神经生长因子联合早期康复干预是一种治疗CMV引起听力损伤的有效方法;其治疗CMV感染轻、中度听力损伤的疗效好于CMV感染重度听力损伤,治疗后天获得性CMV感染听力损伤的疗效好于先天性CMV感染听力损伤。

Objective To explore the effect of rat nerve growth factor combined with early rehabilitation intervention in the treatment of hearing injury caused by cytomegalovirus (CMV) infection.Methods 106 cases of hearing impairment caused by cytomegalovirus infection diagnosed in our hospital from January 2012 to February 2018 were randomly divided into observation group and control group,53 cases in each group.The control group were treated only with ganciclovir and comprehensive rehabilitation therapy,while the treatment group was treated with nerve growth factor on the basis of the control group.Before and after treatment,the children in both groups underwent multi-frequency steady-state evoked potential test,cytomegalovirus antibody DNA fluorescence quantification,and their mothers underwent cytomegalovirus antibody test.The total effective rate of the two groups and the effective rate of the observation group with different degrees of hearing impairment were compared,and the therapeutic effect of the observation group with congenital and acquired CMV infection was compared.Results The total effective rate was 80.7% in the observation group,which was higher than 65.9% in the control group (P<0.05).The effective rate of mild to moderate hearing loss in observation group was higher than that in severe hearing impairment (P<0.05).The efficacy of the rat nerve growth factor in the treatment of hearing loss after CMV infection was higher than that of hearing loss caused by congenital cytomegalovirus infection (P<0.05).Conclusions Rat nerve growth factor combined with early comprehensive rehabilitation intervention is an effective method to treat acoustic nerve injury caused by CMV infection.The effect of rat nerve growth factor on mild and moderate hearing impairment was better than that of severe hearing impairment.The therapeutic effect of acquired CMV infection on hearing damage was better than that of by congenital infection.