钠通道与糖尿病痛性神经病

Voltage-gated sodium channel and painful diabetic neuropathy

钠通道为研究糖尿病痛性神经病(PDN)提供了新思路,本文基于国内外对钠通道和糖尿病痛性神经病及其关系的研究现状,选取了与糖尿病痛性神经病相关性较高的5种钠通道,归纳了这些钠通道的特点,及其在糖尿病痛性神经病模型中的表达状况,总结了钠通道在糖尿病痛性神经病发病机制中作用,分析了钠通道与糖尿病痛性神经病的关系以及目前研究所面临的难题,以期为研究应用钠离子通道治疗糖尿病痛性神经病提供参考。

Sodium channel provides a new idea for the study of painful diabetic neuropathy.Based on the research status of sodium channel and painful diabetic neuropathy at home and abroad,five sodium channels with high correlation with diabetic painful neuropathy were selected,and the characteristics of these sodium channels were summarized.The expression status of sodium channel in diabetic painful neuropathy model was summarized,and the role of sodium channel in the pathogenesis of diabetic painful neuropathy was summarized.The relationship between sodium channel and diabetic painful neuropathy was analyzed,as well as the difficulties facing the current research,in order to provide references for the research and application of sodium channel in the treatment of diabetic painful neuropathy.